Metal-phenolic networks for cancer theranostics

Liu, Peng; Shi, Xinyi; Zhong, Shenghui; Peng, Ying; Yan, Qi; Ding, Jinsong; Zhou, Wenhu

doi:10.1039/d0bm02064h

Cited by 55 publications

(43 citation statements)

References 200 publications

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“…Developing agents with theranostics properties, both therapy and imaging, will improve early cancer detection and overall cancer management. The importance of theranostic agents in the diagnosis and therapy of cancer has been recently reviewed [ 43 , 44 , 45 ]. Since the widely used contrast agent, gadolinium, presents various side effects, we aimed to develop theranostic agents by doping CDs-NHF with ions that present lower toxicity.…”

Section: Discussionmentioning

confidence: 99%

Manganese-Doped N-Hydroxyphthalimide-Derived Carbon Dots—Theranostics Applications in Experimental Breast Cancer Models

et al. 2021

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Background: Theranostics, a novel concept in medicine, is based on the use of an agent for simultaneous diagnosis and treatment. Nanomaterials provide promising novel approaches to theranostics. Carbon Dots have been shown to exhibit anti-tumoral properties in various cancer models. The aim of the present study is to develop gadolinium, Fe3+, and Mn2+-doped N-hydroxyphthalimide-derived Carbon Dots. The resulted doped Carbon Dots should preserve the anti-tumoral properties while gaining magnetic resonance imaging properties. Methods: Normal and cancer cell lines have been treated with doped Carbon Dots, and the cell viability has been measured. The doped Carbon Dots that exhibited the most prominent anti-tumoral effect accompanied by the lowest toxicity have been further in vivo tested. Magnetic resonance imaging evaluates both in vitro and in vivo the possibility of using doped Carbon Dots as a contrast agent. Results: According to the results obtained from both the in vitro and in vivo experimental models used in our study, Mn2+-doped Carbon Dots (Mn-CDs-NHF) exhibit anti-tumoral properties, do not significantly impair the cell viability of normal cells, and reduce lung metastasis and the volume of mammary primary tumors while allowing magnetic resonance imaging. Conclusions: Our findings prove that Mn-CDs-NHF can be used as theranostics agents in pre-clinical models.

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Section: Discussionmentioning

confidence: 99%

Manganese-Doped N-Hydroxyphthalimide-Derived Carbon Dots—Theranostics Applications in Experimental Breast Cancer Models

et al. 2021

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“…As a high Z value element, Cu displays large X-ray attenuation coefficient, making it ideal X-ray computed tomography contrast agent for CT imaging [21] . The FMNs with photothermal conversion performance (CuO, CuS, MPN, Prussian blue et al) induce tissue thermoelastic expansion and hyperthermia under NIR light irradiation, which can be utilized for noninvasive PAI and PTI [114 , 115] .…”

Section: Imaging-guided Cdt-based Therapymentioning

confidence: 99%

Fenton metal nanomedicines for imaging-guided combinatorial chemodynamic therapy against cancer

Liu

Peng

Ding

et al. 2022

Asian Journal of Pharmaceutical Sciences

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“…Polyphenols, such as tannic acid (TA), gallic acid, and epigallocatechin gallate, can assemble with certain metal ions, such as Fe 3+ , Mn 2+ , and Cu 2+ , and then be loaded with chemotherapeutic agents or exist in their pure form. These nanoparticles have been studied in tumor imaging studies that involved magnetic resonance imaging (MRI), CT imaging, photothermal imaging, photoacoustic imaging, as well as tumor therapy photothermal therapy, photodynamic therapy, and chemotherapy [ 8 ]. In this context, metals and polyphenols can display their biological effects via individual or synergistic actions for both diagnostic and therapeutic purposes in cancer treatments [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Systemic Toxicity, Genotoxicity, and Early Phase Hepatocarcinogenicity of Iron (III)-Tannic Acid Nanoparticles in Rats

et al. 2022

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Iron-tannic acid nanoparticles (Fe-TA NPs) presented MRI contrast enhancement in both liver cancer cells and preneoplastic rat livers, while also exhibiting an anti-proliferative effect via enhanced autophagic death of liver cancer cells. Hence, a toxicity assessment of Fe-TA NPs was carried out in the present study. Acute and systemic toxicity of intraperitoneal Fe-TA NPs administration was investigated via a single dose of 55 mg/kg body weight (bw). Doses were then repeated 10 times within a range of 0.22 to 5.5 mg/kg bw every 3 days in rats. Furthermore, clastogenicity was assessed by rat liver micronucleus assay. Carcinogenicity was evaluated by medium-term carcinogenicity assay using glutathione S-transferase placental form positive foci as a preneoplastic marker, while three doses ranging from 0.55 to 17.5 mg/kg bw were administered 10 times weekly via intraperitoneum. Our study found that the LD50 value of Fe-TA NPs was greater than 55 mg/kg bw. Repeated dose administration of Fe-TA NPs over a period of 28 days and 10 weeks revealed no obvious signs of systemic toxicity, clastogenicity, and hepatocarcinogenicity. Furthermore, Fe-TA NPs did not alter liver function or serum iron status, however, increased liver iron content at certain dose in rats. Notably, antioxidant response was observed when a dose of 17.5 mg/kg bw was given to rats. Accordingly, our study found no signs of toxicity, genotoxicity, and early phase hepatocarcinogenicity of Fe-TA NPs in rats.

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Metal-phenolic networks for cancer theranostics

Abstract: Metal-phenolic networks (MPNs) have shown promising potential in biomedicine applications since they provide a rapid, simple and robust way to construct multifunctional nanoplatforms. As a novel nanomaterial self-assembled from metal...

Cited by 55 publications

References 200 publications

Manganese-Doped N-Hydroxyphthalimide-Derived Carbon Dots—Theranostics Applications in Experimental Breast Cancer Models

Manganese-Doped N-Hydroxyphthalimide-Derived Carbon Dots—Theranostics Applications in Experimental Breast Cancer Models

Fenton metal nanomedicines for imaging-guided combinatorial chemodynamic therapy against cancer

Assessment of Systemic Toxicity, Genotoxicity, and Early Phase Hepatocarcinogenicity of Iron (III)-Tannic Acid Nanoparticles in Rats

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