Metal‐organic Framework Sponges

A spectroscopic and computational study of a tough MOF with a fragile linker: Ce-UiO-66-ADC

“…10,11 Since its discovery in 2008, 12 the MOF denoted as UiO-66 [Zr6O4(OH)4(BDC)6], has attracted considerable attention by the scientific community, mainly because of its exceptional toughness: it resists at temperature around 400°C, it shows considerable resistance to hydrolysis and also high tolerance for defects. 13 Moreover, the formation of the cubic lattice by selfassembling of the Zr(IV) clusters (in presence of linear dicarboxylic linkers) is so favoured that the formation of secondary phases, in the same synthetic conditions, is avoided; 14 this encouraged the fruitful research of UiO-66 isostructural derivatives obtained by changing the linker or the metal cation. [15][16][17][18] In this scenario, the present work aimed to introduce the acetylene dicarboxylate (ADC), as linker in the UiO-66 framework and full characterize its peculiar features.…”

Exploring Cyclodextrin-Based Nanosponges as Drug Delivery Systems: Understanding the Physicochemical Factors Influencing Drug Loading and Release Kinetics

“…In the last 15 years, nanosponge particles (named for their sponge-like structure) have been intensively studied due to their possible applications, e.g., as drug carriers, toxin removal agents, or catalysts in organic syntheses [4][5][6][7][8]. Figure 1 presents the diversity of the nanosponge particle family [9][10][11][12][13][14][15][16]; however, most attention is directed towards cyclodextrin-based nanosponges, which were the first to be recognized from the entire group in the late 1990s [17,18]. Dextrin-based polymers evolved from the use of dextrins alone, which itself had growth and stagnation phases.…”