Metal–organic-framework-based pyroptosis nanotuner with long blood circulation for augmented chemotherapy

Zhu, Weichu; Xu, Jingjun; Yao, Xiuzhong; Mai, Shuting; Shu, Dan; Yang, Wuli

doi:10.1039/d3bm00813d

Cited by 5 publications

(1 citation statement)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, Yang et al engineered an acidic pH- and glutathione (GSH)-responsive nanotuner (DOX@ZIF-8@PCBMA-DAC) based on ZIF-8. 49 The researchers first encapsulated DOX with ZIF-8 built by Zn 2+ ions and 2-methylimidazole, which was further coated with the disulfide-crosslinked zwitterionic polymer poly(carboxybetaine methacrylate) (PCBMA) to obtain DOX@ZIF-8@PCBMA (Fig. 2).…”

Section: Mofs As Pyroptosis Inducersmentioning

confidence: 99%

Metal–organic framework (MOF)-based materials for pyroptosis-mediated cancer therapy

Dou,

Wang,

Tian

et al. 2024

Chem. Commun.

View full text Add to dashboard Cite

show abstract

Section: Mofs As Pyroptosis Inducersmentioning

confidence: 99%

Metal–organic framework (MOF)-based materials for pyroptosis-mediated cancer therapy

Dou,

Wang,

Tian

et al. 2024

Chem. Commun.

View full text Add to dashboard Cite

show abstract

Biomaterials Elicit Pyroptosis Enhancing Cancer Immunotherapy

Zhang,

Wang,

Han

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Cancer immunotherapy has the potential to revolutionize the treatment of malignant tumors, but its effectiveness is limited by the low immune response rate and immune‐related adverse events. Pyroptosis, as an inflammatory programmed cell death type, triggers strong acute inflammatory response and antitumor immunity, converting “cold” tumors to “hot”. Particularly, biomaterials loading pyroptosis inducers targeting the tumor microenvironment to engineer pyroptosis, have achieved great progress in recent years. Herein, the design strategy, mechanism pathway, and role of biomaterials to induce pyroptosis in cancer immunotherapy are comprehensively reviewed. The present review focuses on the application of biomaterials‐induced pyroptosis in cancer immunotherapy, including nanogel, polymer prodrug, nanovesicle, and mesoporous material. Additionally, the synthesis of a series of stimuli‐responsive nanoplatforms, including glutathione‐responsive, pH‐responsive, reactive oxygen species‐responsive, and enzyme‐mimicking catalytic performance, is described. Meanwhile, it augments multiple immune response processes of cell uptake, antigen presentation, T‐cell activation, and expansion. Finally, the perspectives of pyroptosis‐mediated inflammation to break through the tumor vascular basement membrane barrier achieving efficient volcanic penetration of biomaterials are discussed. Artificial intelligence, multi‐omics analysis, and anthropogenic animal models of organoids are presented, aiming to provide guidance and assistance for constructing effective and controllable pyroptosis‐engineered biomaterials and improving tumor immunotherapy.

show abstract

Hypoxia-activated cascade nanovaccine for synergistic chemoembolization-immune therapy of hepatocellular carcinoma

Shi,

Zhang,

Zhou

et al. 2024

Biomaterials

View full text Add to dashboard Cite

Metal–organic-framework-based pyroptosis nanotuner with long blood circulation for augmented chemotherapy

Abstract: Pyroptosis is a proinflammatory form of cell death mediated by gasdermin family members, and is a powerful tool against cancer. Herein，a pH-responsive doxorubicin (DOX) encapsulated zeolitic imidazolate framework-8 (ZIF-8) nanoparticle...

Cited by 5 publications

References 46 publications

Metal–organic framework (MOF)-based materials for pyroptosis-mediated cancer therapy

Metal–organic framework (MOF)-based materials for pyroptosis-mediated cancer therapy

Biomaterials Elicit Pyroptosis Enhancing Cancer Immunotherapy

Hypoxia-activated cascade nanovaccine for synergistic chemoembolization-immune therapy of hepatocellular carcinoma

Contact Info

Product

Resources

About