Metal-organic framework-based nanomaterials for biomedical applications

Shu, Zhang; Pei, Xibo; Gao, Huile; Chen, Song; Wang, Jian

doi:10.1016/j.cclet.2019.11.036

Cited by 98 publications

(61 citation statements)

References 160 publications

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“…35,86,87 Moreover, recent progress in designing and manufacturing of MOF nanostructures leading to their novel biomedical applications, such as osteogenesis promotion, [88][89][90] photosensitizer, 91 biomolecule vehicle, 92 Intracellular sensing, 93,94 bioimaging, 95 and biocatalysis. 96 They are highly ordered porous materials composed of metal coordination centers connected by organic linkers. 97 Among them, zeolitic imidazolate frameworks (ZIFs) have attracted intense interest due to their impressive stability along with their high porosity and surface area.…”

mentioning

confidence: 99%

<p>ZIF-8 Modified Polypropylene Membrane: A Biomimetic Cell Culture Platform with a View to the Improvement of Guided Bone Regeneration</p>

Ejeian¹,

Razmjou²,

Nasr-Esfahani³

et al. 2020

IJN

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Purpose Despite the significant advances in modeling of biomechanical aspects of cell microenvironment, it remains a major challenge to precisely mimic the physiological condition of the particular cell niche. Here, the metal–organic frameworks (MOFs) have been introduced as a feasible platform for multifactorial control of cell-substrate interaction, given the wide range of physical and mechanical properties of MOF materials and their structural flexibility. Results In situ crystallization of zeolitic imidazolate framework-8 (ZIF-8) on the polydopamine (PDA)-modified membrane significantly raised surface energy, wettability, roughness, and stiffness of the substrate. This modulation led to an almost twofold increment in the primary attachment of dental pulp stem cells (DPSCs) compare to conventional plastic culture dishes. The findings indicate that polypropylene (PP) membrane modified by PDA/ZIF-8 coating effectively supports the growth and proliferation of DPSCs at a substantial rate. Further analysis also displayed the exaggerated multilineage differentiation of DPSCs with amplified level of autocrine cell fate determination signals, like BSP1, BMP2, PPARG, FABP4, ACAN , and COL2A . Notably, osteogenic markers were dramatically overexpressed (more than 100-folds rather than tissue culture plate) in response to biomechanical characteristics of the ZIF-8 layer. Conclusion Hence, surface modification of cell culture platforms with MOF nanostructures proposed as a powerful nanomedical approach for selectively guiding stem cells for tissue regeneration. In particular, PP/PDA/ZIF-8 membrane presented ideal characteristics for using as a barrier membrane for guided bone regeneration (GBR) in periodontal tissue engineering.

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mentioning

confidence: 99%

<p>ZIF-8 Modified Polypropylene Membrane: A Biomimetic Cell Culture Platform with a View to the Improvement of Guided Bone Regeneration</p>

Ejeian¹,

Razmjou²,

Nasr-Esfahani³

et al. 2020

IJN

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“…Targeted groups of nanoparticles can specifically identify tumor cells, trigger receptor-mediated endocytosis, accelerate the distribution of nano-drugs in tumor tissues, and promote their deep penetration (Liu et al., 2015 ; Ruoslahti, 2017 ; Zhang et al., 2020 ). Many peptides that are effective for penetration in tumor tissues contain the sequence: (R/K)XX(R/K) ( Figure 13(a)( 1)), where X represents an amino acid other than lysine or arginine.…”

Section: Strategies For Promoting Penetration Of Nano-drugsmentioning

confidence: 99%

Recent advances in drug delivery systems for enhancing drug penetration into tumors

Sui

et al. 2020

Drug Delivery

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The emergence of nanomaterials for drug delivery provides the opportunity to avoid the side effects of systemic drug administration and injury caused by the removal of tumors, delivering great promise for future cancer treatments. However, the efficacy of current nano drugs is not significantly better than that of the original drug treatments. The important reason is that nano drugs enter the tumor vasculature, remaining close to the blood vessels and unable to enter the tumor tissue or tumor cells to complete the drug delivery process. The low efficiency of drug penetration into tumors has become a bottleneck restricting the development of nano-drugs. Herein, we present a systematic overview of recent advances on the design of nano-drug carriers in drug delivery systems for enhancing drug penetration into tumors. The review is organized into four sections: The drug penetration process in tumor tissue includes paracellular and transcellular transport, which is summarized first. Strategies that promote tumor penetration are then introduced, including methods of remodeling the tumor microenvironment, charge inversion, dimensional change, and surface modification of ligands which promote tissue penetration. Conclusion and the prospects for the future development of drug penetration are finally briefly illustrated. The review is intended to provide thoughts for effective treatment of cancer by summarizing strategies for promoting the endocytosis of nano drugs into tumor cells.

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“…MOF materials are a class of chemical compounds consisting of metal ions or clusters coordinated to organic ligands to form one-dimensional structure, or two or three-dimensional structures [310] with the capability to form ultrahigh porous materials [311], with up to 90% free volume, and a huge internal surface area extending 6000 m 2 /g [312] Although most of the MOF materials are generally associated with a lack of electrical conductivity [313], a few have been reported as electronic conductors [313,314]. MOF materials have been thoroughly studied for major interests such as heterogeneous catalysis and biomedical applications [315,316].…”

Section: Metal-organic Framework and Mxenesmentioning

confidence: 99%

Blood Pressure Sensors: Materials, Fabrication Methods, Performance Evaluations and Future Perspectives

Al-Qatatsheh

Morsi

Zavabeti

et al. 2020

Sensors

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Advancements in materials science and fabrication techniques have contributed to the significant growing attention to a wide variety of sensors for digital healthcare. While the progress in this area is tremendously impressive, few wearable sensors with the capability of real-time blood pressure monitoring are approved for clinical use. One of the key obstacles in the further development of wearable sensors for medical applications is the lack of comprehensive technical evaluation of sensor materials against the expected clinical performance. Here, we present an extensive review and critical analysis of various materials applied in the design and fabrication of wearable sensors. In our unique transdisciplinary approach, we studied the fundamentals of blood pressure and examined its measuring modalities while focusing on their clinical use and sensing principles to identify material functionalities. Then, we carefully reviewed various categories of functional materials utilized in sensor building blocks allowing for comparative analysis of the performance of a wide range of materials throughout the sensor operational-life cycle. Not only this provides essential data to enhance the materials’ properties and optimize their performance, but also, it highlights new perspectives and provides suggestions to develop the next generation pressure sensors for clinical use.

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Metal-organic framework-based nanomaterials for biomedical applications

Cited by 98 publications

References 160 publications

<p>ZIF-8 Modified Polypropylene Membrane: A Biomimetic Cell Culture Platform with a View to the Improvement of Guided Bone Regeneration</p>

<p>ZIF-8 Modified Polypropylene Membrane: A Biomimetic Cell Culture Platform with a View to the Improvement of Guided Bone Regeneration</p>

Recent advances in drug delivery systems for enhancing drug penetration into tumors

Blood Pressure Sensors: Materials, Fabrication Methods, Performance Evaluations and Future Perspectives

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