Metal/metal oxide nanoparticles: Toxicity concerns associated with their physical state and remediation for biomedical applications

Manuja, Anju; Kumar, Balvinder; Kumar, Rajesh; Dharvi,; Ghosh, Mayukh; Manuja, M.; Brar, Basanti; Pal, Yash; Tripathi, B. N.; Prasad, Minakshi

doi:10.1016/j.toxrep.2021.11.020

Cited by 55 publications

(16 citation statements)

References 118 publications

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“…Judging from the current research popularity of convolutional neural networks, this research has been applied in different fields and there is still some room for improvement in improving network performance. And it lays the foundation for the development of intelligence and automation in future field applications [32,33].…”

Section: Judgment Of the Advantages And Disadvantages Of Rice Growth ...mentioning

confidence: 99%

Metal Oxide Nanomaterials as Rice Transgenic Carriers

Yang

Bai

Zhang

et al. 2022

Advances in Materials Science and Engineering

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For the development of nanotechnology, nanomaterials are in an important position. Due to their special structure and a series of unique properties, nano-metal oxide materials are widely used in nanoelectronics, catalysis, environmental monitoring, electrochemical sensors, and many other fields. Rice, as the most important food crop in the world, has a wide range of planting areas. Therefore, in this paper, the research on the construction of rice transgenic vectors is based on nano-metal oxide materials. In this paper, particle swarm optimization is used to optimize the weights of rice-growing convolutional neural networks. Secondly, it used rice as the test plant to study the effects of seven metal oxide nanomaterials on rice seed germination and root elongation. This sheds light on the toxic effects of metal oxide nanomaterials on rice growth and discusses the factors that affect the phytotoxicity of nanomaterials. The experimental results show that before optimization, the accuracy of the small batch sample test is 87.0456%, the accuracy of the large batch sample test is 93.5876%, and the accuracy of the test is increased by 6.542%. After optimization, the accuracy of the small batch sample test is 93.5876%, the accuracy of the large batch sample test is 99.0133%, and the accuracy of the test is increased by 5.4466%. The inhibition rates of nano-CuO and ZnO on rice root length were 97.28% and 66.75%.

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Section: Judgment Of the Advantages And Disadvantages Of Rice Growth ...mentioning

confidence: 99%

Metal Oxide Nanomaterials as Rice Transgenic Carriers

Yang

Bai

Zhang

et al. 2022

Advances in Materials Science and Engineering

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“…Charged MNPs proved more cytotoxic than neutral forms. Moreover, positively charged MNPs display higher cytotoxicity than negative alternatives of similar size [ 163 , 164 , 165 ].…”

Section: Safety Issues Of Mnps and The Role Of Polysaccharidesmentioning

confidence: 99%

Polysaccharides and Metal Nanoparticles for Functional Textiles: A Review

et al. 2022

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Nanotechnology is a powerful tool for engineering functional materials that has the potential to transform textiles into high-performance, value-added products. In recent years, there has been considerable interest in the development of functional textiles using metal nanoparticles (MNPs). The incorporation of MNPs in textiles allows for the obtention of multifunctional properties, such as ultraviolet (UV) protection, self-cleaning, and electrical conductivity, as well as antimicrobial, antistatic, antiwrinkle, and flame retardant properties, without compromising the inherent characteristics of the textile. Environmental sustainability is also one of the main motivations in development and innovation in the textile industry. Thus, the synthesis of MNPs using ecofriendly sources, such as polysaccharides, is of high importance. The main functions of polysaccharides in these processes are the reduction and stabilization of MNPs, as well as the adhesion of MNPs onto fabrics. This review covers the major research attempts to obtain textiles with different functional properties using polysaccharides and MNPs. The main polysaccharides reported include chitosan, alginate, starch, cyclodextrins, and cellulose, with silver, zinc, copper, and titanium being the most explored MNPs. The potential applications of these functionalized textiles are also reported, and they include healthcare (wound dressing, drug release), protection (antimicrobial activity, UV protection, flame retardant), and environmental remediation (catalysts).

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“…Generally, it is assumed that nanoparticles exhibit low cytotoxicity [11]. However, some scientists raise the issue of the mechanism of nanoparticles accumulation in live organisms, which is not well studied yet [174][175][176][177] especially, that nanoparticle toxicity is related to their structure (dimension and architecture) and characteristics (particle surface charge described by zeta potential, value of polydispersity index, surface functionalization) [178]. Most often, the smaller the particles, the greater their biological activity.…”

Section: Modern Wound Dressing Materials and Nanomaterialsmentioning

confidence: 99%

Composite Membrane Dressings System with Metallic Nanoparticles as an Antibacterial Factor in Wound Healing

et al. 2022

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Wound management is the burning problem of modern medicine, significantly burdening developed countries’ healthcare systems. In recent years, it has become clear that the achievements of nanotechnology have introduced a new quality in wound healing. The application of nanomaterials in wound dressing significantly improves their properties and promotes the healing of injuries. Therefore, this review paper presents the subjectively selected nanomaterials used in wound dressings, including the metallic nanoparticles (NPs), and refers to the aspects of their application as antimicrobial factors. The literature review was supplemented with the results of our team’s research on the elements of multifunctional new-generation dressings containing nanoparticles. The wound healing multiple molecular pathways, mediating cell types, and affecting agents are discussed herein. Moreover, the categorization of wound dressings is presented. Additionally, some materials and membrane constructs applied in wound dressings are described. Finally, bacterial participation in wound healing and the mechanism of the antibacterial function of nanoparticles are considered. Membranes involving NPs as the bacteriostatic factors for improving wound healing of skin and bones, including our experimental findings, are discussed in the paper. In addition, some studies of our team concerning the selected bacterial strains’ interaction with material involving different metallic NPs, such as AuNPs, AgNPs, Fe3O4NPs, and CuNPs, are presented. Furthermore, nanoparticles’ influence on selected eukaryotic cells is mentioned. The ideal, universal wound dressing still has not been obtained; thus, a new generation of products have been developed, represented by the nanocomposite materials with antibacterial, anti-inflammatory properties that can influence the wound-healing process.

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Metal/metal oxide nanoparticles: Toxicity concerns associated with their physical state and remediation for biomedical applications

Abstract: Graphical abstract

Cited by 55 publications

References 118 publications

Metal Oxide Nanomaterials as Rice Transgenic Carriers

Metal Oxide Nanomaterials as Rice Transgenic Carriers

Polysaccharides and Metal Nanoparticles for Functional Textiles: A Review

Composite Membrane Dressings System with Metallic Nanoparticles as an Antibacterial Factor in Wound Healing

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