Composite Membrane Dressings System with Metallic Nanoparticles as an Antibacterial Factor in Wound Healing

Abstract

Wound management is the burning problem of modern medicine, significantly burdening developed countries’ healthcare systems. In recent years, it has become clear that the achievements of nanotechnology have introduced a new quality in wound healing. The application of nanomaterials in wound dressing significantly improves their properties and promotes the healing of injuries. Therefore, this review paper presents the subjectively selected nanomaterials used in wound dressings, including the metallic nanoparticles (NPs), and refers to the aspects of their application as antimicrobial factors. The literature review was supplemented with the results of our team’s research on the elements of multifunctional new-generation dressings containing nanoparticles. The wound healing multiple molecular pathways, mediating cell types, and affecting agents are discussed herein. Moreover, the categorization of wound dressings is presented. Additionally, some materials and membrane constructs applied in wound dressings are described. Finally, bacterial participation in wound healing and the mechanism of the antibacterial function of nanoparticles are considered. Membranes involving NPs as the bacteriostatic factors for improving wound healing of skin and bones, including our experimental findings, are discussed in the paper. In addition, some studies of our team concerning the selected bacterial strains’ interaction with material involving different metallic NPs, such as AuNPs, AgNPs, Fe3O4NPs, and CuNPs, are presented. Furthermore, nanoparticles’ influence on selected eukaryotic cells is mentioned. The ideal, universal wound dressing still has not been obtained; thus, a new generation of products have been developed, represented by the nanocomposite materials with antibacterial, anti-inflammatory properties that can influence the wound-healing process.

A review on contemporary nanomaterial-based therapeutics for the treatment of diabetic foot ulcers (DFUs) with special reference to the Indian scenario

“…Nanomaterials also act as chemical angiogenic substrates to stimulate the growth of blood vessels locally. 16 Nanomaterials stimulate angiogenic effects, allowing the formation of blood vessels in diabetic wounds, promote the migration of endothelial cells, regulate the rearrangement of the cytoskeleton, activate redox signaling and form focal adhesions. 95 The generation of ROS has been shown in redox signaling pathways during the process of angiogenesis.…”

“…cell-type specicity benets unlike the conventional wound dressings or available therapies. [15][16][17] Teaima et al fabricated polyurethane-modied chitosan nanobers encapsulated with various concentrations of linezolid in a diabetic experimental model. The results illustrated that linezolid promoted diabetic wound healing and control the microbial growth at the wound site.…”

“…In the current scenario, nanomaterial-based diabetic wound healing approaches act as powerful weapons against multi-drug-resistant infections and transdermal nanocarriers and possess intrinsic regenerative properties, nanoscaffolds, and nanotopography to prevent biofilm formation, providing cell-type specificity benefits unlike the conventional wound dressings or available therapies. 15–17…”

Nanoparticle-Containing Wound Dressing: Antimicrobial and Healing Effects

“…A number of review articles are known dealing with various wound healing materials, i.e., nanofibers modified with silver nanoparticles [ 14 ], electroconductive films, membranes, hydrogels [ 15 ], nanocomposites based on polylactic acid and zinc oxide nanoparticles [ 16 ], polysaccharide antibacterial hydrogels [ 17 , 18 ], hydrogels with copper nanoparticles [ 19 ], membranes with gold or silver nanoparticles [ 20 ] and others. However, the aforementioned papers do not contain a detailed analysis of antibacterial and healing properties of wound dressings.…”

Simultaneous Release of Silver Ions and 10–Undecenoic Acid from Silver Iron–Oxide Nanoparticles Impregnated Membranes

“…In particular, silver nanoparticles have been extensively studied [11][12][13][14][15] for their biocidal (bactericidal) action, being known and accepted three mechanisms of action on cells (bacteria):…”