Metal/metal oxide nanocomposites for bactericidal effect: A review

Pachaiappan, Rekha; Rajendran, Saravanan; Show, Pau Loke; Manavalan, Kovendhan; Naushad, Mu.

doi:10.1016/j.chemosphere.2020.128607

Cited by 102 publications

(45 citation statements)

References 140 publications

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“…Nanoparticles (NPs) of metal oxide stand out in the field of antimicrobial compounds by their catalytic inhibition activity 1 , 2 . However, their bactericidal mechanism of action (MOA) depends on several parameters, such as their morphology, composition and concentration 3 , 4 .…”

Section: Introductionmentioning

confidence: 99%

Antibacterial action and target mechanisms of zinc oxide nanoparticles against bacterial pathogens

Mendes

Dilarri

Forsan

et al. 2022

Sci Rep

176

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Zinc oxide nanoparticles (ZnO NPs) are one of the most widely used nanoparticulate materials due to their antimicrobial properties, but their main mechanism of action (MOA) has not been fully elucidated. This study characterized ZnO NPs by using X-ray diffraction, FT-IR spectroscopy and scanning electron microscopy. Antimicrobial activity of ZnO NPs against the clinically relevant bacteria Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and the Gram-positive model Bacillus subtilis was evaluated by performing resazurin microtiter assay (REMA) after exposure to the ZnO NPs at concentrations ranging from 0.2 to 1.4 mM. Sensitivity was observed at 0.6 mM for the Gram-negative and 1.0 mM for the Gram-positive cells. Fluorescence microscopy was used to examine the interference of ZnO NPs on the membrane and the cell division apparatus of B. subtilis (amy::pspac-ftsZ-gfpmut1) expressing FtsZ-GFP. The results showed that ZnO NPs did not interfere with the assembly of the divisional Z-ring. However, 70% of the cells exhibited damage in the cytoplasmic membrane after 15 min of exposure to the ZnO NPs. Electrostatic forces, production of Zn2+ ions and the generation of reactive oxygen species were described as possible pathways of the bactericidal action of ZnO. Therefore, understanding the bactericidal MOA of ZnO NPs can potentially help in the construction of predictive models to fight bacterial resistance.

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Section: Introductionmentioning

confidence: 99%

Antibacterial action and target mechanisms of zinc oxide nanoparticles against bacterial pathogens

Mendes

Dilarri

Forsan

et al. 2022

Sci Rep

176

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“…Of the four, Wang et al showed that Fe 3 O 4 @PEG-Gent NPs were the only NPs with S. aureus eradication ability; curcumin-Si, selenium and CS-MP-Ce6 NPs showed only inhibitory function (Wang et al 2018;Lu et al 2019;Tran et al 2019;Mirzahosseinipour et al 2020). This gap can most likely be attributed to the presence of iron oxide in the Fe 3 O 4 @PEG-Gent NPs, as metal oxide NPs have been shown to be particularly effective bactericidal agents due to their uniquely large surface areas containing a vast quantity of reactive sites (Azam et al 2012;Pachaiappan et al 2020). Furthermore, it is notable that both CS-MP-Ce6 NPs-studied by Lu et al-and curcumin-Si NPsstudied by Mirzahosseinipour et al-showed significantly improved levels of S. aureus planktonic inhibition and eradication when combined with the use of a magnetic field and irradiation (near-infrared laser and photodynamic irradiation respectfully) as opposed to NP treatment alone (Lu et al 2019;Mirzahosseinipour et al 2020).…”

Section: Effectiveness Of Np Treatment Against Planktonic S Aureusmentioning

confidence: 99%

The use of functionalized nanoparticles to treat Staphylococcus aureus ‐based surgical‐site infections: a systematic review

2021

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Staphylococcus aureus-based surgical site infections have become the leading cause of failure for total joint arthroplasty operations and remain a major issue across surgical specialties. Moreover, S. aureus-based infections are becoming drastically more difficult to treat due to the development of antibiotic resistant strains and due to the bacteria's propensity to produce biofilms. The emergence of highly resistant S. aureus infections has created the need for a novel antimicrobial treatment. Functionalized nanoparticles have recently been suggested as being a viable option to fill this void due to their strong antimicrobial and antibiofilm properties. However, said research remains a novel and developing field. The presented systematic review aimed to synthesize the best and most recent evidence available to accurately direct new research towards a viable treatment mechanism. In doing so, the authors performed a comprehensive literature search as directed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The results showed that nanoparticles-particularly those including an iron-oxide component or acidic capping agent-are a viable treatment for S. aureus infections both in vivo and in vitro, and show even greater efficacy when combined with exposure to a magnetic field and irradiation.

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“…They can spread diseases between humans in various ways, seriously threatening human life and health, and hindering the development of society 1 . In the long struggle against bacteria, humans have already possessed a variety of weapons, such as the applications of physical methods (temperature 2,3 , radiation 4,5 , and electrical stimulation 6 ), chemical methods (antibiotics 7,8 , metals, and metal oxides [9][10][11] ), and biological methods (bacteriophage 12 , and biological control bacteria 13 ). However, physical methods are often limited by the lack of exogenous stimuli.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, it is particularly important to develop new antibacterial materials as soon as possible to protect human health. Reactive oxygen species (ROS) are one of the main reasons for the bactericidal effect of many natural substances 11,14 . ROS are single-electron reduction product of oxygen.…”

Section: Introductionmentioning

confidence: 99%

The chemodynamic antibacterial effect of MnO_X nanosheet decorated silicon nanowire arrays

Guize

Wang

et al. 2022

Mater. Adv.

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Metal/metal oxide nanocomposites for bactericidal effect: A review

Cited by 102 publications

References 140 publications

Antibacterial action and target mechanisms of zinc oxide nanoparticles against bacterial pathogens

Antibacterial action and target mechanisms of zinc oxide nanoparticles against bacterial pathogens

The use of functionalized nanoparticles to treat Staphylococcus aureus ‐based surgical‐site infections: a systematic review

The chemodynamic antibacterial effect of MnO_X nanosheet decorated silicon nanowire arrays

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Metal/metal oxide nanocomposites for bactericidal effect: A review

Cited by 102 publications

References 140 publications

Antibacterial action and target mechanisms of zinc oxide nanoparticles against bacterial pathogens

Antibacterial action and target mechanisms of zinc oxide nanoparticles against bacterial pathogens

The use of functionalized nanoparticles to treat Staphylococcus aureus ‐based surgical‐site infections: a systematic review

The chemodynamic antibacterial effect of MnOX nanosheet decorated silicon nanowire arrays

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The chemodynamic antibacterial effect of MnO_X nanosheet decorated silicon nanowire arrays