Metal ions induce bone-resorbing cytokine production through the redox pathway in synoviocytes and bone marrow macrophages

Niki, Yasuo; Matsumoto, Hideo; Suda, Yasunori; Otani, Toshiro; Fujikawa, Kyosuke; Toyama, Yoshiaki; Hisamori, Noriyuki; Nozue, Akira

doi:10.1016/s0142-9612(02)00531-8

Cited by 77 publications

(43 citation statements)

References 46 publications

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“…There is a potential for released metal ions to alter local osteoblast and osteoclast homeostasis at the bone-implant interface, leading to peri-prosthetic bone loss. Several studies have shown that metal ions from implants can cause osteolysis by inflammatory cytokine stimulation or cytotoxicity to the cells in the tissue surrounding the implants [24,[26][27][28][29]. In addition to the triggering of phagocytosis inflammatory pathways by wear particles, here we report that osteoclast differentiation and activation is directly induced by low concentrations of soluble Co 2þ ion.…”

Section: Discussionsupporting

confidence: 55%

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Effects of soluble cobalt and cobalt incorporated into calcium phosphate layers on osteoclast differentiation and activation

2009

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Section: Discussionsupporting

confidence: 55%

“…Previous reports also examined the effects of metal corrosion products and ions on proinflammatory cytokine production. Metal ions enhance the release of IL-1b and TNF-a by human monocyte/ macrophage cells, while metal debris enhances the release of PGE2 by osteoblasts [24,28,29].…”

Section: Introductionmentioning

confidence: 99%

Effects of soluble cobalt and cobalt incorporated into calcium phosphate layers on osteoclast differentiation and activation

2009

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“…Particle uptake by macrophages and metal ion effects on osteoblasts influence the production of M-CSF and RANKL as well as elicit the production of proinflammatory cytokines (IL-1, IL-6, IL-11, TNF-α), prostaglandins (PGE +2 ) and TGF-β. It is likely that this can have a significant impact on osteoclast activity (60,61). Although both MCSF and RANKL have been identified as key players in osteoclast differentiation and activation, recent studies suggest these factors may also play a role in osteoclast survival.…”

Section: Effects On Osteoclastsmentioning

confidence: 99%

The effects on bone cells of metal ions released from orthopaedic implants. A review

Sansone

Pagani

Melato

2013

CCMBM

167

182

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SummaryThe increasing use of orthopedic implants and, in particular, of hip and knee joint replacements for young and active patients, has stimulated interest and concern regarding the chronic, long-term effects of the materials used. This review focuses on the current knowledge of the adverse biologic reactions to metal particles released from orthopaedic implants in vivo and in vitro. More specifically, the purpose of this article is to provide an overview of the current literature about the adverse effects of metal particles on bone cells and peri-implant bone.

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“…They play a role in inflammation, host defence, and reactions against a range of autologous and foreign substances. 11) Their functions involve the release of inflammatory mediators, including the production of cytokines, such as interleukin-1 (IL-1) and tumor necrosis factor-(TNF-). The amount of the production of these cytokines is proportional to the degree of inflammation reaction of the macrophage.…”

Section: Preparation Of Corrosion Productsmentioning

confidence: 99%

Evaluation of Biocompatibility for Titanium-Nickel Shape Memory Alloy <I>in Vivo</I> and <I>in Vitro</I> Environments

et al. 2007

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This study was conducted to evaluate the biocompatibility of titanium-nickel shape memory alloy used as a medical implant material. The authors carried out the following electrochemical corrosion test and in vivo and in vitro biological tests for the alloy and some metal and alloys clinically used previously to compare the intensities concerned with the biological reactions, that is, (1) anodic polarization test for the alloy in a quasi-body fluid, (2) cell proliferation tests for pure titanium (cp Ti), pure nickel (cp Ni), SUS316L stainless steel, titanium-6 mass% aluminium-4 mass% vanadium (Ti-6Al-4V), and titanium-55 mass% nickel (Ti-55Ni) by using of L929 fibroblastic cells, (3) Lactate dehydrogenaze (LDH), human interlukin-1 (hIL-1), and human tumor necrosis factor-(hTNF-) biochemical assays by using of U937 human macrophages administered the corrosion products of these alloys for the cells, (4) measurement of the mount of excretions of the metallic corrosion products of Ti-55Ni, SUS316L stainless steel, and Ti-6Al-4V with urine and feces injected into the abdomen cavity of Wistar rats, and (5) tissue reaction observations for SUS316L, Ti-55Ni, and cp Ni wires implanted along the femoral bone axis of the rats.The following results were obtained. (1) The pitting corrosion potentials of Ti-55Ni alloy was drastically improved by the aging treatment. (2) In the case of Ti-55Ni alloy, the inflammatory cytokines, hIL-6 and hTNF-were suppressed to lower levels compared with Ti-6Al-4V alloy. (3) Corrosion products prepared from the titanium alloys were stable in the body. Then it is very hard to eliminate the titanium ions with urine and feces. (4) Ti-55Ni alloy was shown an excellent biocompatibility evaluated by the in vivo implantation test, because of the stable passive film formed on the surface and protected the metal ion release to the surrounding tissue.

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Metal ions induce bone-resorbing cytokine production through the redox pathway in synoviocytes and bone marrow macrophages

Cited by 77 publications

References 46 publications

Effects of soluble cobalt and cobalt incorporated into calcium phosphate layers on osteoclast differentiation and activation

Effects of soluble cobalt and cobalt incorporated into calcium phosphate layers on osteoclast differentiation and activation

The effects on bone cells of metal ions released from orthopaedic implants. A review

Evaluation of Biocompatibility for Titanium-Nickel Shape Memory Alloy <I>in Vivo</I> and <I>in Vitro</I> Environments

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