Metal ion coordination of macromolecular bioligands: formation of zinc(II) complex of hyaluronic acid

Burger, K.; Illés, János; Gyurcsik, Béla; Gazdag, M.; Forrai, Erika; Dékány, Imre; Mihályfi, K.

doi:10.1016/s0008-6215(01)00065-9

Cited by 33 publications

(19 citation statements)

References 20 publications

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“…Consequently, also polysaccharides are capable as O-ligate metal ions [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. Particular attention has been paid to starch as the ligand of metal ions.…”

Section: Introductionmentioning

confidence: 99%

Starch–metal complexes and their rheology

Ciesielski¹,

Krystyjan²

2009

E-Polymers

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Changes in conductivity of 5 w/w% starch gels was studied on their titration with 0.1 M aqueous solutions of selected metal salts. Starch gels usually trapped around 10 mg metal ions per 1 g starch [Co(II), Cu(II), Fe(III), Ni(II)] and that value was only slightly dependent on starch origin (amaranthus, corn, potato, tapioca, waxy corn). Among salts studied (acetates, chlorides, nitrates) FeCl 3 and NiCl 2 were likely to be used because they hydrolyzed increasing conductivity of the solutions and formed micelles of corresponding hydroxides adhering to starch micelles and increasing amount of trapped metal. Addition of metal salts to starch gels had a devastating effect on pseudoplasticity and viscosity of starch gels and only potato starch gel was to a certain extent, exceptional in that respect.

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Section: Introductionmentioning

confidence: 99%

Starch–metal complexes and their rheology

Ciesielski¹,

Krystyjan²

2009

E-Polymers

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“…First row transition metal elements play important role in human life [1] and chemists are interested in co-ordination compounds for their application in industrial and synthetic processes, such as chemical, biological, environmental, ionexchange catalysis, photochemistry, and biological applications, Moreover their thermal, spectral, microscopic and many other properties have also been examined [2][3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…Many of these complexes have unusual physical, chemical and structural properties. The N,N-diethyldithiocarbamate (dtc), has itself been widely used in the earlier transition metals [14] in which, for example, the apparently simple complexes M (dtc) 2 (M (II) = chromium, manganese, iron, copper and zinc) actually involve 5-co-ordination [15]. They has been found to act as a uninegative bidentate ligand, coordinating through both sulfur atoms [16], and both four-and six-coordinated complexes of a number of transition metal ions have been isolated [17].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Thermal Studies of Transition Metal Complexes with O-, S-Donor Ligands

Ramzan¹,

Saleem²,

Ali³

et al. 2017

JAPLR

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Transition metal carboxylates have been synthesized with transition metal chlorides of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Ru(III). The binding ligands are 3-[(4-bromophenylamido)]propenoic acid (L) and diethyl dithiocarbamate. All these compounds have been characterized by elemental analyses, conductivity measurements, UV/Vis, FT-IR spectroscopy and thermal analysis. Semi empirical studies of three compounds have also been carried out for structural elucidation showing that the Cr and Co derivatives have a six coordinated octahedral geometry which is in accordance with the data obtained from elemental analysis, UV/visible and FTIR spectroscopy. Thermal studies of all synthesized derivatives were carried out in a temperature range of 50-1000°C under inert atmosphere. Their kinetic parameters, like activation energy, enthalpy, entropy and order of reaction, were also studied. All complexes decompose at a certain temperature leaving behind metal oxides as residual products. The synthesized complexes showed remarkable anti-bacterial activities with a few exceptions. Selected compounds were also investigated for DNA damage assay.

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“…Several counterion-HA complexes have been prepared to investigate the potential effects of various cations. [7][8][9][10][11] Balogh and colleagues investigated the degradation and antioxidant activities of counterion-HA complexes and reported that these complexes are therapeutically more effective than Na-HA. Among the counterion-HA complexes, zinc hyaluronate (Zn-HA) exerts a positive effect against the antioxidant activity, unlike Na-HA.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effects of zinc hyaluronate on synoviocyte growth and matrix metalloproteinase-9 activity

Saito¹

2009

JIR

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Sodium hyaluronate (Na-HA) is a therapeutic agent used for treating knee arthritis. However, it has been unsuccessfully used in the treatment of knee effusions. Joint effusion results from synovial activation and growth, leading to an increase in the production of matrix metalloproteinases (MMPs), especially MMP-9. This study aimed to determine whether the newly developed zinc hyaluronate (Zn-HA) is more effective than Na-HA in inhibiting the growth of synoviocytes or production and activity of MMPs in rheumatoid synoviocytes. Our results showed that Zn-HA inhibited synoviocyte growth, MMP-9 protein production, and MMP-9 mRNA expression, whereas Na-HA exerted only a slight inhibitory effect on these parameters. Moreover, Zn-HA induced synoviocyte apoptosis, whereas Na-HA did not. These results suggest that Zn-HA retards synoviocyte growth by inducing apoptosis following a decrease in the production of MMP-9 and mRNA. Therefore, it is suggested that Zn-HA can suppress arthritis more efficiently than Na-HA.

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Metal ion coordination of macromolecular bioligands: formation of zinc(II) complex of hyaluronic acid

Cited by 33 publications

References 20 publications

Starch–metal complexes and their rheology

Starch–metal complexes and their rheology

Synthesis, Characterization and Thermal Studies of Transition Metal Complexes with O-, S-Donor Ligands

Inhibitory effects of zinc hyaluronate on synoviocyte growth and matrix metalloproteinase-9 activity

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