“…Six compounds ( 3aa , 3r ′, 3s , 5s, 6r ′, 6s ) were evaluated for their inhibition of the cell TPC-1 viability in vitro by the CCK-8 assay (Scheme ). The test results showed that most of them have stronger in vitro growth inhibitory activities than cisplatin (IC 50 = 0.85 μM), with IC 50 values of 0.50, 0.27, 0.38, 0.31, 0.19, and 0.90 μM. In particular, 6r ′ performed far better than cisplatin, which will be contributed to future drug design due to the great antineoplastic potential exhibited in this skeleton.…”