Site-Selective Benzylic C–H Hydroxylation in Electron-Deficient Azaheterocycles
Milanpreet Kaur,
Julian C. Cooper,
Jeffrey F. Van Humbeck
Abstract:Benzylic C–H bonds can be converted into numerous functional groups, often by mechanisms that involve hydrogen atom transfer at the key bond breaking step. The abstracting species is most often an electrophilic radical, which makes these reactions best suited to electron-rich C–H bonds to achieve appropriate polarity matching. Thus, electron deficient systems such as pyridine and pyrimidine are relatively unreactive, and relatively underrpresented in substrate scopes. In this report, we describe a new method f… Show more
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