Metal composition of fine particulate air pollution and acute changes in cardiorespiratory physiology

Cakmak, Sabit; Dales, Robert; Kauri, Lisa Marie; Mahmud, Mamun; Ryswyk, Keith Van; Vanos, Jennifer; Liu, Ling; Kumarathasan, Premkumari; Thomson, Errol M.; Vincent, Renaud; Weichenthal, Scott

doi:10.1016/j.envpol.2014.03.004

Cited by 165 publications

(76 citation statements)

References 37 publications

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“…Published studies have reported that Zn compound exposure is associated with increased CVD mortality rate in the United States and PM-associated Zn relates to cardiac injury in rats Kodavanti et al, 2008). It was also reported that Zn, Pb in PM 2.5 can lead to heart rate and blood pressure increase (Cakmak et al, 2014). In addition, PAHs are also suggested to be associated with CVD (Baxter et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

The involvement of Nox4 in fine particulate matter exposure-induced cardiac injury in mice

Wu¹,

Zhang²

2018

J. Toxicol. Sci.

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-Epidemiological studies have confirmed that ambient fine particulate matter (PM 2.5 ) exposure is associated with cardiovascular disease (CVD). However, the underlying mechanisms in PM 2.5 exposure-induced heart injury are largely unknown. It has been acknowledged that NADPH oxidase (Nox) 4 plays a critical role in CVD development. To investigate the acute effects of PM 2.5 on the mouse heart and the role of Nox4 in PM 2.5 exposure-induced cardiac injury, C57BL/6J mice were instilled with saline or 1.5, 3.0, 6.0 mg/kg BW PM 2.5 suspension for two weeks (five days per week). The levels of malondialdehyde (MDA), super oxide dismutase (SOD), inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α) and interleukin (IL)-1β in heart supernatants were determined using related kits. The expression of Nox4, p67 phox , p47 phox and p22 phox in heart tissue was evaluated by immunofluorescence staining or Western blotting, respectively. Protein levels of p53, Bax, Bcl-2 and Caspase-3 in the heart were examined using immunohistochemical staining and Western blotting. TUNEL assay was used to measure myocardial apoptosis. PM 2.5 exposure leads to obvious cardiac injury. PM 2.5 exposure increases MDA level and iNOS activity, and decreases activity of SOD in heart supernatants of mice. High levels of TNF-α and IL-1β in heart supernatants of mice with PM 2.5 instillation were determined. Nox4 and Noxassociated subunits such as p67 phox , p47 phox and p22 phox expression levels were increased in heart tissue of mice after PM 2.5 exposure. Additionally, PM 2.5 exposure causes myocardial apoptosis in the mouse heart. This study suggested that Nox4 is involved in PM 2.5 exposure-induced cardiac injury in mice.

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Section: Discussionmentioning

confidence: 99%

The involvement of Nox4 in fine particulate matter exposure-induced cardiac injury in mice

Wu¹,

Zhang²

2018

J. Toxicol. Sci.

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“…Numerous studies revealed that exposure to airborne particulate matter results in significant acute and chronic health implications such as respiratory illness, cardio-respiratory related morbidity and mortality, cardiovascular diseases, neurodigeneratitive disorders, and adverse birth outcomes (Wang et al 2013;Cakmak et al 2014;Zanobetti et al 2014, and references herein). Recently, IARC classified outdoor air and airborne particulate matter as carcinogens (IARC 2013).…”

Section: Introductionmentioning

confidence: 97%

“…PM components such as metals (i.e., Fe, K, Ti, Br, Cr, Ni, Na, V, Ca, Cd, Pb, Sr, and Zn), organic/elemental carbon and organic constituents in airborne particulate matter were associated with acute changes in cardiorespiratory physiology, higher cardiovascular hospital admissions, or cardiovascular deaths (Ostro et al 2007; Responsible editor: Gerhard Lammel Electronic supplementary material The online version of this article (doi:10.1007/s11356-015-4559-7) contains supplementary material, which is available to authorized users. Franklin et al 2008;Zanobetti et al 2009;Bell et al 2009;Cakmak et al 2014).…”

Section: Introductionmentioning

confidence: 98%

“…Possible health impacts through inhalation are related to both particle size of particulate matter and associated constituents (Wiseman and Zereini 2014;Zanobetti et al 2009;Puls and al. 2012;Zanobetti et al 2014;Cakmak et al 2014) Lately, various studies focus on the distribution of inorganic and organic pollutants in different aerosol sizes due to possible environmental and health risks (Čupr et al 2013;Degrendele et al 2014;Landlová et al 2014;Romanazzi et al 2014;Besis et al 2015).…”

Section: Introductionmentioning

confidence: 99%

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Size distribution of total and water-soluble fractions of particle-bound elements—assessment of possible risks via inhalation

Voutsa

Anthemidis

Giakisikli

et al. 2015

Environ Sci Pollut Res

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The size distribution of total and water-soluble elemental concentrations in six particle sizes <0.49, 0.49-0.97, 0.97-1.5, 1.5-3.0, 3.0-7.2, and 7.2-30 μm was investigated in Thessaloniki area, N. Greece, at two sites representing urban-traffic and urban-background character during the cold and warm period. The elements As, Cd, Cr, Cu, Pb, Ni, Zn, Ru, and Ir exhibited their highest mass portion in the fine particle mode (0.97-1.5 μm), whereas Al, Ba, Ca, Fe, and Mn occurred predominately in the coarse particle mode (3.0-7.2 μm). The water-soluble elemental fractions exhibited significant spatiotemporal variations and particle size dependence. Possible non-carcinogenic and carcinogenic risks associated with inhalation of particle-bound elements based on total and water-soluble concentrations were in acceptable levels. However, the cumulative risk for all potential particle-bound constituents has to be considered.

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“…Cerium and lanthanum are also reported in the environmental tobacco smoke and may produce inflammation and granulomatosis in lung tissue [17]. Cakmak [18] found association with respiratory effects and the content of Cd, Zn and V in particulate matter (PM 2.5 ] and the suggested mechanism was oxidative stress resulting in inflammation and tissue damage.…”

Section: Respiratory System and Metalsmentioning

confidence: 99%

Health Effects of Metals in Particulate Matter

Fortoul¹,

Rodríguez-Lara²,

González-Villalva³

et al. 2015

Current Air Quality Issues

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Metal composition of fine particulate air pollution and acute changes in cardiorespiratory physiology

Abstract: Metals contained in PM2.5 were found to be associated with acute changes in cardiovascular and respiratory physiology.

Cited by 165 publications

References 37 publications

The involvement of Nox4 in fine particulate matter exposure-induced cardiac injury in mice

The involvement of Nox4 in fine particulate matter exposure-induced cardiac injury in mice

Size distribution of total and water-soluble fractions of particle-bound elements—assessment of possible risks via inhalation

Health Effects of Metals in Particulate Matter

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