Metal complexes of the third-generation quinolone antimicrobial drug sparfloxacin: Structure and biological evaluation

Copper(II) complexes with antimicrobial drug flumequine: Structure and biological evaluation

“…For complex 5, a lowintensity band at 703 nm (ε =50 M − 1 cm − 1 ) is observed assigned to a 2 E g ➔ 2 T 2g d-d transition, typical for Cu(II) complexes with octahedral local symmetry. The complexes also exhibit a shoulder at 400-411 nm (ε =130-210 M − 1 cm − 1 ) which may be assigned to ligand-to-metal charge-transfer transition, as it has been observed in a series of quinolones-metal complexes, while the UV part of the spectra is similar with that of flumequine not shown substantial differences due to the presence of nitrogen-donor ligands (bipyam, bipy, phen or py) [43][44][45][46][47][48].…”

“…Our recent studies have been focused on the study of divalent Co(II), Ni(II), Cu(II) or Zn(II) complexes with antimicrobial [10,[43][44][45][46][47][48][49][50] or antiinflammatory drugs [17,18,[51][52][53] in the absence or presence of N-donor(s) heterocyclic ligands. Taking into consideration the significance of the quinolones in medicine [1][2][3][4] and the fact that metal complexes with drugs may exhibit more pronounced biological properties in comparison to the free drugs, we have initiated the interaction of Cu(II) with quinolones [15,16,29,33,[36][37][38].…”

Antibacterial Activities and Nuclease Properties of Two New Ternary Copper(II) Complexes with 2‐(4′‐Thiazolyl)‐benzimidazole and 2,2′‐Bipyridine/1,10‐phenanthroline

“…The antimicrobial activity of metal complexes is generally concerned with the following factors: 44 (1) The chelate effect, i.e. ligands that are bound to central metal ions in a multidentate fashion, (2) the nature of the ligands, (3) the total charge of the complex, (4) the nature of the counter ion in the case of the ionic complex, and (5) the nuclearity of the metal in the complex.…”

Nickel–quinolones interaction. Part 4 — Structure and biological evaluation of nickel(II)–enrofloxacin complexes compared to zinc(II) analogues

“…Our studies have been focused on the coordination chemistry and the biological activity of carboxylate-containing antimicrobial [13][14][15][37][38][39][40][41] or anti-inflammatory [12,[42][43][44][45] agents with metal ions in an attempt to examine their mode of binding and possible biological relevance. Taking into consideration the reported biological role and activity of nickel and its complexes, the significance of the quinolones in medicine and the fact that metal complexes with drugs may exhibit more pronounced biological properties in comparison to the free drugs, we have initiated the study of nickel(II) complexes with quinolone antimicrobial agents [30][31][32][33].…”