Antibacterial Activities and Nuclease Properties of Two New Ternary Copper(II) Complexes with 2‐(4′‐Thiazolyl)‐benzimidazole and 2,2′‐Bipyridine/1,10‐phenanthroline

Abstract

The complexes showed good antibacterial activities against the microorganisms. The interaction between the complexes and calf thymus DNA in aqueous solution was investigated adopting electronic absorption spectroscopy, fluorescence spectroscopy, viscosity measurements and cyclic voltammetry. Results suggest that the two complexes can bind to DNA by intercalative mode. In addition, the result of agarose gel electrophoresis suggested that the complexes can cleave the plasmid DNA at physiological pH and room temperature. Mechanistic studies with different inhibiting reagents reveal that hydroxyl radicals, and a singlet oxygen-like copper-oxo species are all involved in the DNA scission process mediated by the complexes.

Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity

“…This indicates that the antibacterial activity of the complexes can be attributed predominantly to the synergistic activity of the central copper(II) ion and the ligands in the complexes and the existence of bipy (2,2 -bipyridine) or phen (1,10-phenanthroline) co-ligands. Furthermore, the antibacterial activity in Tz-26a is in agreement with its DNA binding and cleavage behaviour [91].…”

Direct conversion of alkyl halides into benzimidazoles using pyridine-N-oxide and 1,2-diaminobenzenes

“…16 Benzimidazole-based copper and zinc complexes display analgesic, antipyretic, anti-inflammatory, 17 antitumor 18 and nuclease activity. 19,20 Some of the d10 transition metal coordination polymers based on bis(benzimidazole) ligands show luminescent properties 21 and cobalt(II) benzimidazole complexes have been used as catalysts in polymerization reactions. 22 Benzimidazoles are usually synthesized by condensation between carboxylic acids or their functional derivatives and o-aminoanilines.…”