Metal complexes of the antibiotic nalidixic acid

Behrens, Noráh Barba; DIAZ, G. MENDOZA; Goodgame, D. M. L.

doi:10.1016/s0020-1693(00)85478-x

Cited by 62 publications

(18 citation statements)

References 11 publications

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“…The average CuAN bond lengths in the molecule are ca. 2.0 Å , similar to the mixed-ligand copper complex, containing phenanthroline and cinoxacin (Cnx) described by Mendoza-Diaz et al [27]. The bite angle of the phenanthroline ligand in the present compound is found to be 82.4(2)°analogous to the previously reported values [25].…”

Section: Bond Lengthssupporting

confidence: 90%

Metalloantitubercular compounds Part 3: Synthesis, crystal structure, spectroscopy, electrochemistry and antimycobacterial activity of the copper(II) ciproploxacin (cfH) complex and its phenanthroline adduct

Saha

Patitungkho

Padhyé

et al. 2005

Transition Met Chem

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The X-ray crystal structures of two ciprofloxacin compounds, viz. [Cu(cfH) 2 (Cl) 2 ] Á 2MeOH Á 6H 2 O (2) and [Cu(cfH)(phen)Cl]BF 4 Á 4H 2 O (3) are reported. Complex (2) has a distorted octahedral geometry, whereas for the nitrogen adduct (3) a distorted square-pyramidal geometry is seen. Significant enhancement in the antimycobacterial activity of the copper conjugates correlates with their copper redox couples (Cu 2+ /Cu + ) probably due to its relevance to intracellular accumulations and subsequent role in generating oxidative stress.

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Section: Bond Lengthssupporting

confidence: 90%

Metalloantitubercular compounds Part 3: Synthesis, crystal structure, spectroscopy, electrochemistry and antimycobacterial activity of the copper(II) ciproploxacin (cfH) complex and its phenanthroline adduct

Saha

Patitungkho

Padhyé

et al. 2005

Transition Met Chem

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“…The Fe(Asp) 2 C1 3 complex was insoluble in CDC1 3 , therefore the signals obtained were mainly the solvent peaks 8 .…”

Section: Resultsmentioning

confidence: 99%

“…However, it is known that some drugs act via chelation or by inhibiting metalloenzymes but for most of the drugs that act as potential ligands, a lot of studies are being carried out to ascertain how metal binding influences the activities of the drugs 3 . Although, in 1987, AbuEl-Wafa et al 4 reported the synthesis of Co(ii), Ni(ii) and Fe(ii) complexes of metformin(L), also an analgesic, on the basis of analytical data obtained, the prepared complexes were formulated as ML 2 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and antibacterial activity of aspirin and paracetamolmetal complexes

Lawal¹,

Obaleye²

2010

Biokemistri

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Novel complexes of Co (11), Ni (11) and Fe (111) with aspirin and paracetamol have synthesized and characterized using infrared, electronic and Hnmr spectral, melting point and conductivity measurements. The two ligands have been found to act as bidentate chelating agents. Aspirin complexes coordinate through the carbonyl oxygen of the carboxyl and the ester groups, while paracetamol complexes coordinate through the oxygen of the hydroxyl and the amide groups. Antibacterial screening of the complexes against Bacillus substilis, Serratia species and Escherichia coli, was also investigated. The metal complexes were found to have varied degree of inhibitory effect against the bacteria.

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“…9). 25,30 The IR spectrum corresponding to HCl.NOR 3 Al obtained by method II displays no differences with respect to that of the sample obtained by method I.…”

mentioning

confidence: 99%

NMR and IR characterization of the aluminium complexes of norfloxacin and ciprofloxacin fluoroquinolones

Chattah

Linck

Monti

et al. 2007

Magnetic Reson in Chemistry

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A set of new aluminium complexes of norfloxacin (NOR) and ciprofloxacin (CIP) that show an improvement in their pharmaceutical properties were studied using solution and solid-state nuclear magnetic resonance (NMR) and infrared (IR) spectroscopy. The complexes synthesized with two different methods were compared. One of these methods will allow formulation of the compounds at production scale. High-resolution (13)C spectra were obtained with the cross-polarization and magic angle spinning (CP-MAS) experiment. These spectra were assigned by comparing them with the solution data of the pure drug and by using a quaternary carbon edition technique. The carbon relaxation times in the rotating frame, T(1rhoC), were measured for all the complexes. A two-exponential decay evidences that the complexes are nonhomogeneous. The short T(1rhoC) values are in the range 320-1100 micros and the long values in the range 1.8-7 ms. (27)Al MAS NMR spectra revealed an octahedral coordination between the aluminium ion and oxygens of the pure drug, supporting a 3:1 ligand:metal stoichiometry in both CIP and NOR complexes. The stretching and deformation modes of carboxylic acid and carboxylate and keto groups were analyzed by IR. This technique shows that the same modes are present in the aluminium complexes obtained by the two methods and that the coordination of the fluoroquinolone to aluminium occurs through the 4-keto and 3-carboxylic groups.

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Metal complexes of the antibiotic nalidixic acid

Cited by 62 publications

References 11 publications

Metalloantitubercular compounds Part 3: Synthesis, crystal structure, spectroscopy, electrochemistry and antimycobacterial activity of the copper(II) ciproploxacin (cfH) complex and its phenanthroline adduct

Metalloantitubercular compounds Part 3: Synthesis, crystal structure, spectroscopy, electrochemistry and antimycobacterial activity of the copper(II) ciproploxacin (cfH) complex and its phenanthroline adduct

Synthesis, characterization and antibacterial activity of aspirin and paracetamolmetal complexes

NMR and IR characterization of the aluminium complexes of norfloxacin and ciprofloxacin fluoroquinolones

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