Metal complexes of salicylhydroxamic acid (H2Sha), anthranilic hydroxamic acid and benzohydroxamic acid. Crystal and molecular structure of [Cu(phen)2(Cl)]Cl·H2Sha, a model for a peroxidase-inhibitor complex

Comparison of Adsorption of Phenol O-O and N-O Chelating Collectors at the Malachite/Water Interface in Flotation

“…At pH 3 to 9, the higher precipitation and/or adsorption degree of salicylaldoxime on the malachite surface than that of salicyl hydroxamate might be attributed to the different stability constants of these chelating reagents with Cu 2+ complexes. The stability constants of Cu-salicylaldoxime and Cu-salicyl hydroxamate are 12 and 9.05 [19,20], respectively, indicating that it is easier for salicylaldoxime to react with Cu 2+ complexes in the form of cupric precipitates or adsorption on the malachite surface. It is notable from previous discussions that salicyl hydroxamate has a lower adsorption density on the malachite surface (Figure 4), but modifies the malachite surface to be more negative than salicylaldoxime (Figure 3).…”

Hydroxamic Acids: Chemistry, Bioactivity, and Solutionand Solid‐Phase Synthesis

“…Typically, hydroxamic acids chelate metal ions via the carbonyl oxygen and deprotonated hydroxyl oxygen to form stable singly deprotonated hydroxamato complexes, although coordination via the deprotonated nitrogen may also occur under certain reaction conditions to give doubly deprotonated hydroximato derivatives [16,17]. Their strong affinity for transition metal ions is reflected in the magnitudes of their overall stability constants (log b values) [18] which for trisbenzohydroxamato Fe(III), for example, is 27.20 [19]. The hydroxamic acid moiety also contains multiple sites for hydrogen bonding interactions (Scheme 3.1), often crucial structural elements that can confer selectivity to a drug for its biological target or indeed increase the binding of a drug to its receptor [16,20].…”

“…MOE (Molecular Operating Environment) from the Chemical Computing Group (www.chemcomp.com) was used to draw these figures. 10 Structures of aspirin(19), O-acetylsalicylhydroxamic acid (20)[73] triacetylsalicylhydroxamic acid (21)[74], and anthranilic hydroxamic acid(22).…”

Self-assembly and cytotoxicity study of waterwheel-like dinuclear metal complexes: The first metal complexes appended with multiple free hydroxamic acid groups

“…A fire-new mode was found in crystal 1, in which the strong metal ion chelate functioned hydroxamic acid groups are uncoordinated. To our knowledge, it was the first example that real hydroxamic acid metal complexes with multiple free biological hydroxamic acid groups discovered in crystal structures [41]. There are more than 1000 structurally characterized transition metal species having the classic dimetal paddlewheel structure, which just provide a 'think tank' for designing functional metal-organic frameworks (MOFs) [42].…”