Metal Chelates of Sulfafurazole Azo Dye Derivative: Synthesis, Structure Affirmation, Antimicrobial, Antitumor, DNA Binding, and Molecular Docking Simulation

Abstract

A series of divalent and one trivalent metal chelates of the azo ligand resulting from coupling of sulfafurazole diazonium chloride with resorcinol have been designed and synthesized. Structure investigation of the isolated chelates have been achieved by applying spectroscopic and analytical tools which collaborated to assure the formation of the metal chelates in the molar ratios of 1L: 1M for Ni(II), Co(II), and Fe(III) chelates, where Cu(II) and Zn(II) complexes formed in the ratio 2L : 1M. The geometrical arrangement around the metal canters was concluded from UV-Vis spectra to be octahedral for all metal chelates. The attachment of the ligand to the metal ions took place through the azo group nitrogen and o-hydroxyl oxygen through proton displacement leading to the ligand being in monobasic bidentate binding mode. Antimicrobial and antitumor activities of the interested compounds have been evaluated against alternative microorganisms and cancer cells, respectively, in a trial to investigate their extent of activity in addition to docking studies. The mode of interaction of the compounds with SS-DNA has been examined by UV-Vis spectra and viscosity studies.

Synthesis, characterization and anticancer activity of Ni(II), Cu(II), Pd(II) and Au(III) complexes derived from novel Mannich base

“…Non-platinum active compounds are likely to have mechanism of action, bio distribution and toxicity which are different from those of platinum drugs and might be effective against human cancers that are poor chemo sensitivity or have become resistant to conventional platinum drugs. On the other hand some Cu(II) and Ni(II) complexes introduced to have the ability to bind with DNA [33][34][35] and the nanosized complexes also have antitumor efficacy in sev-eral cancer cell lines. 36 Au(III) as well as Pd(II) complexes have gotten a lot of interest in the development of novel metal anticancer medicines, they also have similar behavior of platinum against cancer cell lines.…”

Exploring the antimicrobial, antioxidant and cytotoxic activities of organyltellurium (IV) complexes incorporating 2‐hydroxy‐1‐naphthaldehyde schiff base ligand: Synthesis, spectroscopic investigations and theoretical studies

“…[5][6][7] However, these drugs exhibit several drawbacks including toxicity, cumulative side effects, limited spectrum of activity and non-specific targeting. 8 Hence, there is a pressing need for novel chemotherapeutic drug with reduced side effects. Analyzing the current situation, we performed the cytotoxicity of the synthesized Schiff base ligandbased Organyltellurium (IV) complexes.…”

Investigation of anti‐inflammatory and antimicrobial activities of hydrazone‐based diorganotin (IV) complexes: Synthesis, spectroscopic characterization, and computational studies

“…Diorganotin (IV) complexes are a class of chemical compounds that consist of a central tin atom that is covalently bonded to two organic groups and various ligands, which makes them versatile and useful in different areas such as catalysis, 17 polymer chemistry, 18 biological activity 19–21 and material science. Among various ligand scaffolds used in tin complexes, hydrazones are notable for their unique chelating properties owing to the presence of an additional chelating center as C=O in addition to the functional group (HN=CH)C=, which allows them to coordinate with different metal ions as either protonated or deprotonated species, forming a diverse array of homo‐ and hetero‐chelates with distinct geometrical structures.…”