Metal Cationization Extractive Electrospray Ionization Mass Spectrometry of Compounds Containing Multiple Oxygens

Abstract

Extractive electrospray ionization is an ambient ionization technique that allows real-time sampling of liquid samples, including organic aerosols. Similar to electrospray ionization, the composition of the electrospray solvent used in extractive electrospray ionization can easily be altered to form metal cationized molecules during ionization simply by adding a metal salt to the electrospray solvent. An increase in sensitivity is observed for some molecules that are lithium, sodium, or silver cationized compared with the protonated molecule formed in extractive electrospray ionization with an acid additive. Tandem mass spectrometry of metal cationized molecules can also significantly improve the ability to identify a compound. Tandem mass spectrometry of lithium and silver cationized molecules can result in an increase in the number and uniqueness of dissociation pathways relative to [M + H]. These results highlight the potential for extractive electrospray ionization with metal cationization in analyzing complex aerosol mixtures. Graphical Abstract ᅟ.

Characterization of galacto‐oligosaccharides using high‐performance anion exchange chromatography‐tandem mass spectrometry

“…With the same β‐(1→6)‐linkage, 1,6‐β‐ d ‐galactosyl‐glucose shows relatively higher abundance in m/z 101.02 and m/z 221.07 (Figure 4F), compared to 1,6‐β‐galactobiose, which shows a unique fragment at m/z 125.02 (Figure 4E). Overall, the fragmentations display a neutral loss of water from fragment ions, which is common among carbohydrates and other oxygen‐containing compounds [32].…”

“…As shown in Figure 4 4E). Overall, the fragmentations display a neutral loss of water from fragment ions, which is common among carbohydrates and other oxygen-containing compounds [32].…”

Quantification of pentaerythritol tetrastearate, a mold release agent used in polycarbonate, by non‐aqueous RP HPLC method

“…The ammonium adduct ion formation was due to addition of ammonium acetate as an additive in the mobile phase . Sodium adduct ion formation was because of partial negative charge on oxygen of PETS . Molecular formula generation tool of MassHunter qualitative software was used to generate empirical formulae for the high‐resolution mass spectra of PETS components.…”

Investigating the exceptional adducts of alkoxides with Ru(II)–arene cations in alkyl alcohol solution using electrospray ionization mass spectrometry

“…Considering that the solvent is a primary factor in determining ionization efficiency and ion species produced in ESI‐MS, 27 exploring the interaction of Ru(II)–arene complexes with various solvents could provide references for solvent selection and structure identification. In the work reported here, two kinds of Ru(II)–arene complexes, namely Ru‐[1 5 ]PCPs and Ru(II)–arene dimers, dissolved in various solvents were investigated using ESI‐MS combined with hydrogen/deuterium exchange (HDX) experiments and density functional theory (DFT) calculations, with a view to further understand the stability of the Ru(II)–arene complexes in solution and their interactions with the solvent.…”