Metal‐catalyzed Synthesis of Epoxides

Three‐Membered Heterocycles. Structure and Reactivity

“…The topic of metal-based catalysis for alkene epoxidation is expansive, and the reader is directed to two excellent reviews of this chemistry by Adolfsson [398] and Adolfsson and Balan [399], as well as an outstanding treatise on mechanism and kinetics by Oyama [400] and an overview of asymmetric methods by Matsumoto and Katsuki [401]. The development of (salen)metal complexes (Figure 2.13) for the epoxidation of alkenes has been nothing less than revolutionary, providing access to epoxides from simple olefins in much the same way Sharpless chemistry paved the way for the epoxidation of functionalized alkenes.…”