Metal‐Catalyzed Approaches for the Construction of Azepinones

Abstract

The azepinone scaffolds are an important framework of pharmaceutically interesting compounds and many bioactive natural products. This review mainly focused on the metalcatalyzed approaches towards the synthesis of azepinones . Mainly it covers cycloisomerization and metal carbenoid insertion. It also involves transformations through cycloaddition reactions, metathesis reactions, microwave reactions and direct CÀ H/CÀ C/CÀ N activation reactions. The applications, substrate scope, limitations and plausible mechanisms of these transformations have also been discussed.