Metal-catalysed synthesis of nitroenaminones from α-nitroketones or -esters and nitriles

Additions to Metal-Activated Organonitriles

“…The reactions of β -dicarbonyls, β -ketoamides, β -ketophosphonates, or phosphonoacetates, exhibiting strong C−H acidity, with nitriles which are based on the use of metal(II) centers as homogeneous catalysts have already been reviewed, in 1993, and later updated by additional experimental works − from the same authors, and therefore, this topic will not be treated herein. The metal-mediated reaction between β -dicarbonyls and nitriles have also been extended to acyl cyanides, and it was observed that [Ni(acac) 2 ] (4 mol %) or [Cu(acac) 2 ] , (5 mol %) catalyze the addition of β -diketones to RCOCN to give, e.g., the enamino diketones 267 depicted in Scheme .…”