Additions to Metal-Activated Organonitriles

Synthetic Applications of the Parkins Nitrile Hydration Catalyst [PtH{(PMe2O)2H}(PMe2OH)]: A Review

“…The conversion of nitriles into amides by conventional acid/base strategies usually requires harsh conditions and remains impractical for most purposes due to yield and selectivity issues, since these classical methods are frequently unable to control the over-hydrolysis of the primary amide product [7,8]. The use of transition metal complexes (mainly of as catalysts under neutral and mild conditions has allowed researchers to overcome these traditional barriers, and a large number of selective catalysts for the nitrile hydration process have seen the light during the last two decades [9][10][11][12][13][14][15]. Among them, the commercially available hydride-platinum(II) complex [PtH{(PMe2O)2H}(PMe2OH)] (1), first described by Ghaffar and Parkins in 1995 [16,17], has achieved great success among organic chemists because of its outstanding activity and selectivity and its exquisite compatibility with other functional groups ( Figure 1).…”

[Cu40Se16(S-C6H4-CN)8(dppm)8]: A Disc-like Copper Cluster with a Nitrile-functionalized Ligand Shell

“…Synthesis of [Cu 40 Se 16 (S-C 6 H 4 -CN) 8 (dppm) 8 ] (1) Initially, the synthesis of small nitrile-functionalized copper thiolate clusters was intended by the reaction of CuOAc with 4-mercaptobenzonitrile in the presence of tertiary phosphanes. In contrast to the results obtained with silver [25], the variation of the stoichiometry, the tertiary phosphane, the solvent and other reaction parameters such as temperature, in these reactions usually resulted in the quantitative formation of insoluble yellow precipitates, which are assumed to be oligomeric or even polymeric copper thiolates.…”

Coordination Aspects in Modern Inorganic Chemistry

“…Reactivity of metal complexes is an important area of coordination chemistry [47][48][49][50], including reactions on coordinatively-unsaturated donor centers 52, 59 [14,17,25,26] or metals complex-formers 54-57 [14, 41,42], as well as reactions of self-assembling, leading to various supramolecular structures [19][20][21]. Reactions of coordinated inorganic and organic ligands are of the high interest.…”

“…Reactions of coordinated inorganic and organic ligands are of the high interest. In particular, in 1998-2007 reactivity of such ligands as nitriles (RCN) and oximes, coordinated to the ion Pt(IV) is intensively studied [50][51][52][53][54][55][56][57][58][59][60][61][62]. The main attention in these studies is given to the reactions of nucleophylic addition of various nucleophiles on the carbon atom of triple CN-bond of the nitrile fragment, whose electrophylic activation was reached because of its coordination to Pt(IV) 96.…”