Synthetic Applications of the Parkins Nitrile Hydration Catalyst [PtH{(PMe2O)2H}(PMe2OH)]: A Review

Abstract

Abstract:The air-stable hydride-platinum(II) complex [PtH{(PMe2O)2H}(PMe2OH)], reported by Parkins and co-workers in 1995, is the most versatile catalyst currently available for the hydration of C≡N bonds. It features remarkable activity under relatively mild conditions and exceptionally high functional group compatibility, facts that have allowed the implementation of this complex in the synthesis of a large number of structurally complex, biologically active molecules and natural products. In this contribution, synthetic applications of the Parkins catalyst are reviewed.

Selective Hydration of Nitriles to Corresponding Amides in Air with Rh(I)-N-Heterocyclic Complex Catalysts

“…To avoid this problem, in the last decades several remarkable catalytic systems have been developed to stop hydration at the amide stage, e.g., using enzymes as biocatalysts (nitrile hydratase, NHase) [3], nanocatalysts such as a Fe 3 O 4 magnetic nanoparticles-supported Cu-NHC complex [4], or ruthenium hydroxide nanoparticles on magnetic silica [5], silver nanoparticles [6], and other heterogeneous [7][8][9][10] or homogenous catalysts. A broad spectrum of transition metal complexes based on rhodium [11,12], ruthenium [12][13][14][15], nickel [16], osmium [17], and gold [18] were employed as catalysts, and the field has been reviewed from various aspects [19][20][21][22][23][24][25][26][27][28][29].…”

Arene-Osmium(II) Complexes in Homogeneous Catalysis

“…For these particular substrates, the effectiveness of complex 52a was superior to that of [RuCl 2 (η 6 -p-cymene)(PMe 2 OH)] and the Parkins catalyst [PtH{(PMe 2 O) 2 H}(PMe 2 OH)]. In this sense, it should be noted that, despite being recognized as the most versatile nitrile hydration catalyst reported to date in the literature [118], the latter resulted completely inoperative.…”

Analysis of Possibilities to Improve Ecological Operating Parameters of Modern Compression – Ignition Diesel Engines

“…heating) or use a substance which easily reacts with a substrate (low activation energy), and the resulting compound easily converts into a final product (low activation energy, too). A substance which thus facilitates the conversion from substrates to products is being called a catalyst [6]. A catalyst, after conversion of substrates into products, regenerates completely, hence sometimes it is possible to encounter a wording that a catalyst is a substance that does not participate in the reaction but only facilitate its progress.…”