Metal Carbonyl Prodrugs: CO Delivery and Beyond

Romão, M.J.; Vieira, Helena L.A.

doi:10.1002/9783527673438.ch06

Cited by 14 publications

(23 citation statements)

References 136 publications

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“…Examples are the ruthenium analogues of staurosporine kinase inhibitors developed by Meggers 7. More recently, certain metal carbonyl complexes, known as CO‐releasing molecules (CORMs), have been used to release CO for application in therapy 8,9. The chemical reactivity of certain complexes has also been exploited.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Biological Properties of Osmium‐Based Tamoxifen Derivatives – Comparison with Their Homologues in the Iron and Ruthenium Series

et al. 2015

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Keywords: Drug design / Antitumor agents / Osmium / Ruthenium / Metallocenes / Ferrocifen Three osmium analogues 3a-3c of hydroxytamoxifen were prepared. The antiproliferative effects of these complexes were measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and compared with those of their homologues of ferrocene (1a-1c) and ruthenocene (2a-2c). The tamoxifen-like complexes 2c and 3c derived from osmium and ruthenium show good cytotoxicities against the two cell lines (IC 50 values between 2 and 3 μM), albeit lower than those of ferrocifen 1c (IC 50 between 0.5 and 0.8 μM). These complexes induce senescence of the cells at low concentration (0.5 μM). The mono-and diphenol complexes of osmium and ruthenium show little cytotoxicity against the two cell lines (2a, 2b, 3a, 3b; IC 50 ≈ 30 μM), whereas the iron analogues show

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Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Biological Properties of Osmium‐Based Tamoxifen Derivatives – Comparison with Their Homologues in the Iron and Ruthenium Series

et al. 2015

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“…This type of compounds is known as CO-releasing molecules (CORMs) [32,33]. However, their use as antitumour agents has not been well developed.…”

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confidence: 99%

Selective cytotoxicity of arene tricarbonylchromium towards tumour cell lines

Elloumi-Mseddi

Mnif

Akacha

et al. 2018

Journal of Organometallic Chemistry

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“…Therefore, a group of transition metal carbonyls or boranocarbonates, known as CO-releasing molecules (CORMs), which can release CO upon transformation becomes the best alternative to gas administration [ 2 – 5 , 9 , 10 ]. Since high concentrations of CO are proven to be cytotoxic via inhibition of the mitochondrial respiratory system [ 11 , 12 ], CORMs offer a possible strategy for a local release of high amounts of CO for specific cytotoxicity only to the tumour region [ 1 ].…”

Section: Carbon Monoxide-releasing Molecules (Corms)mentioning

confidence: 99%

“…Since 1949 when carbon monoxide (CO) was firstly identified as a natural metabolite in the exhaled air of healthy humans, it took a long time to be recognised as a molecular mediator. CO has been classified with other biologically active diatomic molecules, such as nitrogen oxide (NO) and hydrogen sulphide (H 2 S), as a gasotransmitter [ 1 ]. Naturally, CO is an inert gas, colourless, odourless, tasteless, and nonirritating.…”

Section: Introductionmentioning

confidence: 99%

“…CO exerts antiapoptotic, anti-inflammatory, and antioxidant effects, being able to maintain cell and tissue homoeostasis. It also acts as an antiproliferative and vasodilator agent and may be involved in tissue regeneration and strengthen the innate immune system [ 1 , 3 ]. There is much evidence supporting the beneficial effects of CO in a vast array of diseases, such as cardiovascular disorders, sepsis and shock, cancer, acute and chronic rejection after organ transplantation, kidney and liver dysfunctions, haematological diseases, hypertension, inflammation, and neurodegeneration [ 2 – 4 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Aspects of Carbon Monoxide in Form of CO‐Releasing Molecules Used in Cancer Treatment: More Light on the Way

Kourti

Jiang

Cai

2017

Oxidative Medicine and Cellular Longevity

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Carbon monoxide (CO) has always been recognised as a toxic gas, due to its higher affinity for haemoglobin than oxygen. However, biological studies have revealed an intriguing role for CO as an endogenous signalling molecule, a gasotransmitter. CO is demonstrated to exert many cellular activities including anti-inflammatory, antiapoptotic, and antiproliferative activities. In animal studies, CO gas administration can prevent tissues from hypoxia or ischemic-reperfusion injury. As a result, there are a plethora of reports dealing with the biological applications of CO and CO-releasing molecules (CORMs) in inflammatory and vascular diseases. CORMs have already been tested as a therapeutic agent in clinical trials. More recently, an increased interest has been drawn to CO's potential use as an anticancer agent. In this review, we will aim to give an overview of the research focused on the role of CO and CORMs in different types of cancer and expand to the recent development of the next generation CORMs for clinical application in cancer treatment.

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Metal Carbonyl Prodrugs: CO Delivery and Beyond

Cited by 14 publications

References 136 publications

Synthesis, Characterization, and Biological Properties of Osmium‐Based Tamoxifen Derivatives – Comparison with Their Homologues in the Iron and Ruthenium Series

Synthesis, Characterization, and Biological Properties of Osmium‐Based Tamoxifen Derivatives – Comparison with Their Homologues in the Iron and Ruthenium Series

Selective cytotoxicity of arene tricarbonylchromium towards tumour cell lines

Aspects of Carbon Monoxide in Form of CO‐Releasing Molecules Used in Cancer Treatment: More Light on the Way

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