Metal-based sulfonamides: Their preparation, characterization and<i>in-vitro</i>antibacterial, antifungal &amp; cytotoxic properties. X-ray structure of 4-[(2-hydroxybenzylidene) amino] benzenesulfonamide

Chohan, Zahid H.

doi:10.1080/14756360701384195

Cited by 25 publications

(10 citation statements)

References 49 publications

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“…Compound (4) showed significant (50%) activity against (d), and (1) and (2) weaker (19 and 24%) against (e) and (a), respectively. Compounds (3) and (5) similarly showed weaker (14-20%) activity against (f), and the same weaker (21%) activity was observed for compound (4) against (b) [55][56][57] .…”

Section: Antifungal Bioassay (In Vitro)mentioning

confidence: 67%

Some biologically active oxovanadium(IV) complexes of triazole derived Schiff bases: their synthesis, characterization and biological properties

Chohan

Sumrra

2010

Journal of Enzyme Inhibition and Medicinal Chemistry

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Section: Antifungal Bioassay (In Vitro)mentioning

confidence: 67%

Some biologically active oxovanadium(IV) complexes of triazole derived Schiff bases: their synthesis, characterization and biological properties

Chohan

Sumrra

2010

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Among Schiff bases the N,O ‐coordinating Schiff bases are of particular interest due to their unusual configuration toward transition metals and many of these complexes assisted as models for biologically important species 45,46 . The metal complexes derived from sulfonamide conjugated Schiff bases with chromium, manganese, iron, cobalt, nickel, copper and zinc metal ions have shown potential applications as antibacterial, 8,9,47–52 antifungal, 10,53–55 anticancer, 10,56–58 antioxidant, 59,60 anti‐inflammatory, 61 and carbonic anhydrase enzyme inhibition 62,63 and as catalyst, 64,65 respectively.…”

Section: Resultsmentioning

confidence: 99%

Sulfonamide derived Schiff base Mn (II), Co (II), and Ni (II) complexes: Crystal structures, density functional theory and Hirshfeld surface analysis

Shehnaz

Siddiqui

Ashraf

et al. 2023

Applied Organom Chemis

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The three transition metal complexes of the ligand named as 2,4‐dibromo‐6‐{[2‐(1,1‐dioxo‐1H‐benzoisothiazole‐3‐yl‐amino)‐ethylimino]‐methyl}‐phenol 3 were synthesized with divalent manganese, cobalt and nickel metal ions and characterized by employing different analytical methods including UV–visible, FT‐IR and elemental analyses. The crystal structures of Mn (II) complex 4, Co (II) complex 5, and Ni (II) complex 6 are determined by single beam X‐rays crystallography, which confirm the distorted octahedral coordination of the complexes 4–6. The non‐covalent interactions of the complexes 4–6 are investigated by the Hirshfeld surface analysis. The tendency of the pair of chemical species to form crystal packing interactions are computed, which provide the favorable contacts in the crystal packing for the complexes 4–6. For the sake of computing strength of the crystal packing, void analysis is performed for the complexes 4–6. The non‐electrolytic nature of synthesized metal complexes was confirmed by molar conductance. The spectral analyses suggested that sulfonamide functionalized Schiff base behaves as bidentate ligand and coordinates with the metal center through phenolic oxygen and iminic nitrogen atoms. The density functional theory (DFT) studies were performed for the Mn (II), Co (II), and Ni (II) metal complexes at the B3LYP/LANL2DZ level of theory. The structural characteristics, vibrational analysis (IR), NMR analysis, UV–Vis, natural bonding orbital (NBO), frontier molecular orbital (FMO), charges (Mulliken and NPA), global reactivity descriptors, molecular electrostatic potential (MEP), and dipole moments were investigated using this method. The large values of stabilization energy, that is, 12.02, 15.25, and 23.81 kcal/mol were found for the complexes Mn (II) 4, Co (II) 5, and Ni (II) 6, respectively by NBO analysis. The global reactivity findings suggested the positive values of electron affinity for all complexes, which indicate the involvement of charge transfer reaction. Among these complexes, complex 6 is the most stable and complex 4 is the least. Further, FMO analysis indicated large HOMO‐LUMO gap (3.85–3.97 eV) with higher LUMO values for all metal complexes.

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“…(Touzani et al, 2001;Waring et al, 2002). b ORTEP diagram of a single molecule found in the asymmetric unit (Chohan, 2008;Chohan et al, 2009) …”

Section: Resultsmentioning

confidence: 99%

Petra, Osiris and Molinspiration (POM) together as a successful support in drug design: antibacterial activity and biopharmaceutical characterization of some azo Schiff bases

et al. 2011

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Herein, we report the design and calculated molecular properties of ten existing azo Schiff bases 5a-h and 7a, b. On the basis of a hypothetical antibacterial pharmacophore, the structures are designed to interact with Gram-positive and Gram-negative bacteria. The in vitro biological evaluation of these compounds allowed us to point out new potential non-nucleoside hits, with MIC values in the range of 2-8 lg/ml active against Staphylococcus aureus and Bacillus subtilis. In contrast to Gram positive strains, no activity is noted in favor of Gram negative strains (Klebsiella pneumonia, Pseudomonas aeruginosa and Escherichia coli). The antibacterial activity of these azo Schiff bases is discussed on the basis of theoretical calculations by using Petra, Osiris and Molinspiration (POM) model.

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Metal-based sulfonamides: Their preparation, characterization andin-vitroantibacterial, antifungal & cytotoxic properties. X-ray structure of 4-[(2-hydroxybenzylidene) amino] benzenesulfonamide

Cited by 25 publications

References 49 publications

Some biologically active oxovanadium(IV) complexes of triazole derived Schiff bases: their synthesis, characterization and biological properties

Some biologically active oxovanadium(IV) complexes of triazole derived Schiff bases: their synthesis, characterization and biological properties

Sulfonamide derived Schiff base Mn (II), Co (II), and Ni (II) complexes: Crystal structures, density functional theory and Hirshfeld surface analysis

Petra, Osiris and Molinspiration (POM) together as a successful support in drug design: antibacterial activity and biopharmaceutical characterization of some azo Schiff bases

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