Metal-Based NO Sensing by Selective Ligand Dissociation

Franz, Katherine J.; Singh, Nisha; Lippard, Stephen J.

doi:10.1002/1521-3773(20000616)39:12<2120::aid-anie2120>3.0.co;2-m

Cited by 107 publications

(63 citation statements)

References 12 publications

(18 reference statements)

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“…This general approach relies on quenching of pendant fluorophores by coordination to a paramagnetic and/or heavy-metal centre, where NO can selectively displace and release the fluorophore by metal–ligand substitution with a concomitant emission turn-on response. This strategy has been applied to a broad spectrum of coordination chemistry motifs; examples include iron cyclam 64 , cobalt aminotroponimine 65 , ruthenium porphyrin 63 and dirhodium tetracarboxylate 66 platforms.…”

Section: Metal-mediated Reaction-based Fluorescent Probesmentioning

confidence: 99%

Reaction-based small-molecule fluorescent probes for chemoselective bioimaging

2012

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The dynamic chemical diversity of elements, ions and molecules that form the basis of life offers both a challenge and an opportunity for study. Small-molecule fluorescent probes can make use of selective, bioorthogonal chemistries to report on specific analytes in cells and in more complex biological specimens. These probes offer powerful reagents to interrogate the physiology and pathology of reactive chemical species in their native environments with minimal perturbation to living systems. This Review presents a survey of tools and tactics for using such probes to detect biologically important chemical analytes. We highlight design criteria for effective chemical tools for use in biological applications as well as gaps for future exploration.

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Section: Metal-mediated Reaction-based Fluorescent Probesmentioning

confidence: 99%

Reaction-based small-molecule fluorescent probes for chemoselective bioimaging

2012

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“…While there appears to be no recent work reported, the example of Lippard is included for completeness (Scheme 5). 14 In 2009, Strano and coworkers demonstrated that a diaminophenyl-functionalised dextran polymer enables the rapid and direct response of single-wall nanotubes (SWNTs) to nitric oxide. 15 Since this "early" discovery, this group went on to prepare fluorescent SWNT-based sensors comprised of singlestranded d(AT)15 DNA oligonucleotide-encased nanotubes (AT15-SWNT).…”

Section: Detection Of Nitric Oxidementioning

confidence: 99%

New reagents for detecting free radicals and oxidative stress

Olia

Schiesser

Taylor³

2014

Org. Biomol. Chem.

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Free radicals and oxidative stress play important roles in the deterioration of materials, and free radicals are important intermediates in many biological processes. The ability to detect these reactive species is a key step on the road to their understanding and ultimate control. This short review highlights recent progress in the development of reagents for the detection of free radicals and reactive oxygen species with broad application to materials science as well as biology.

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“…For some time, there has been an interest in possible utilization of the NO reduction of coordinated metal complexes of luminescent ligands as turn-on sensors for NO detection [142,143]. In this context, it is of interest that in weakly coordinating solvents, the cuprous complex Cu(dmp) 2 + is strongly luminescent from its metal-to-ligand charge transfer (MLCT) state(s), while the Cu(II) analog is not [144].…”

Section: +mentioning

confidence: 99%