New reagents for detecting free radicals and oxidative stress

Olia, Mina Barzegar Amiri; Schiesser, Carl H.; Taylor, Michelle K.

doi:10.1039/c4ob01172d

Cited by 23 publications

(17 citation statements)

References 80 publications

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“…They can be derived from oxygen, nitrogen, or sulfur molecules. Free radicals derived from oxygen are usually called reactive oxygen species (ROS) [ 8 , 9 ]. The main forms of cardiac ROS are superoxide (O 2 −• ), hydrogen peroxide (H 2 O 2 ), hydroxyl radicals ( • OH), and peroxynitrite (ONOO − ).…”

Section: Reactive Oxygen Speciesmentioning

confidence: 99%

Cardiopulmonary Bypass and Oxidative Stress

Zakkar

Guida

Suleiman

et al. 2015

Oxidative Medicine and Cellular Longevity

131

106

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The development of the cardiopulmonary bypass (CPB) revolutionized cardiac surgery and contributed immensely to improved patients outcomes. CPB is associated with the activation of different coagulation, proinflammatory, survival cascades and altered redox state. Haemolysis, ischaemia, and perfusion injury and neutrophils activation during CPB play a pivotal role in oxidative stress and the associated activation of proinflammatory and proapoptotic signalling pathways which can affect the function and recovery of multiple organs such as the myocardium, lungs, and kidneys and influence clinical outcomes. The administration of agents with antioxidant properties during surgery either intravenously or in the cardioplegia solution may reduce ROS burst and oxidative stress during CPB. Alternatively, the use of modified circuits such as minibypass can modify both proinflammatory responses and oxidative stress.

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Section: Reactive Oxygen Speciesmentioning

confidence: 99%

Cardiopulmonary Bypass and Oxidative Stress

Zakkar

Guida

Suleiman

et al. 2015

Oxidative Medicine and Cellular Longevity

131

106

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show abstract

“…Free radicals are relatively reactive molecules derived from oxygen, nitrogen, or sulphur molecules. Since these radicals are usually derived from oxygen, these molecules are called as reactive oxygen molecules (reactive oxygen species/ROS) [ 1 , 2 ]. ROS is the products of normal metabolism such as aerobic metabolism in mitochondria in ATP production.…”

Section: Introductionmentioning

confidence: 99%

The Effect of On‐Pump and Off‐Pump Bypass Operations on Oxidative Damage and Antioxidant Parameters

Doğan

Türker

2017

Oxidative Medicine and Cellular Longevity

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Objective The aim of the study is to determine the oxidative status in on-pump and off-pump coronary artery surgery and contribute to possible surgical choices in clinical practices in accordance with the information obtained as a result of this study. Methods 52 patients undergoing open heart surgery (26 patients in on-pump group and 26 patients in off-pump group) were included in the study. MDA, GPx, GSH, CAT, and SOD were investigated in blood samples. Results In the on-pump group, it was determined that there were a significant increase in MDA level in the peroperative period compared to the preoperative and postoperative periods and a significant increase in GSH level in the postoperative period than in the preoperative period. Additionally, while there was a significant decrease in CAT activity in the postoperative period than in the peroperative period, there was a statistically significant increase in SOD enzyme activity in the postoperative period compared to the preoperative and peroperative periods. A statistically significant increase was observed in SOD enzyme activity in the postoperative period in on-pump compared to off-pump group. Conclusion It is thought that this oxidative damage can be suppressed by administering a suitable antioxidant supplement in the preoperative and peroperative periods among patients undergoing the on-pump operation.

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“…36 In living cells the probe is reduced to a hydroxylamine by common antioxidants such as vitamin C and glutathione resulting in a fluorescence enhancement. 37 A pyrene-ferrocene dyad 10 connected via a 2,3-diaza-1,3butadiene spacer is another form of redox-luminescent switch (Fig. 15 Nitroxides tethered to CdSe and carbon QDs have also been shown to effectively quench the luminescence by PET.…”

Section: Redox-luminescent Pet Switchesmentioning

confidence: 99%

Photoinduced electron transfer as a design concept for luminescent redox indicators

Magri

2015

Analyst

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The general design principle for developing luminescent redox indicators based on photoinduced electron transfer is described. The first part of the review introduces colorimetric and fluorimetric redox indicators. The second part of the review highlights recent developments regarding molecular luminescent redox switches and logic gates. Potential future applications in biology, environmental analysis, biomedical diagnostics, corrosion science and materials science are mentioned.

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New reagents for detecting free radicals and oxidative stress

Cited by 23 publications

References 80 publications

Cardiopulmonary Bypass and Oxidative Stress

Cardiopulmonary Bypass and Oxidative Stress

The Effect of On‐Pump and Off‐Pump Bypass Operations on Oxidative Damage and Antioxidant Parameters

Photoinduced electron transfer as a design concept for luminescent redox indicators

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