Metal-Assisted Hydrolysis Reactions Involving Lipids: A Review

Williams, Dominique E.; Grant, Kathryn B.

doi:10.3389/fchem.2019.00014

Cited by 12 publications

(11 citation statements)

References 37 publications

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“…DUBs are grouped into eight classes, according to their enzymatic cleavage preferences: ( i ) The Ubiquitin-Specific Proteases (USP/UBP), ( ii ) Ubiquitin C-terminal Hydrolases (UCH), ( iii ) Ovarian Tumor Proteases (OTU), ( iv ) Machado-Josephin Domain (MJD) DUBs, ( v ) Motif Interacting with Ub-containing Novel DUB (MINDY; cysteine proteases), ( vi ) c-Jun Activation domain-Binding protein-1 (JAB1)/Moloney leukemia virus-34 Proviral Integration (MOV34)/Mannose 6-Phosphate Receptor 1 (MPR1)/Proteasome-Associated PAD1 Homolog (PAD1) N-terminal (MPN) Domain-Associated Metallopeptidases (JAMM), ( vii ) Monocyte Chemotactic Protein-Induced Protein (MCPIP), and ( viii ) the recently discovered Zinc Finger with Ubiquitin Fold Modifier 1 (UFM1)-Specific Peptidase Domain Protein proteases (ZUFSP) [ 29 , 30 ].…”

Section: Ubiquitin As a Versatile Signal To Regulate The Immune Responsementioning

confidence: 99%

Negative Regulation of the Innate Immune Response through Proteasomal Degradation and Deubiquitination

Budroni

Versteeg

2021

Viruses

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The rapid and dynamic activation of the innate immune system is achieved through complex signaling networks regulated by post-translational modifications modulating the subcellular localization, activity, and abundance of signaling molecules. Many constitutively expressed signaling molecules are present in the cell in inactive forms, and become functionally activated once they are modified with ubiquitin, and, in turn, inactivated by removal of the same post-translational mark. Moreover, upon infection resolution a rapid remodeling of the proteome needs to occur, ensuring the removal of induced response proteins to prevent hyperactivation. This review discusses the current knowledge on the negative regulation of innate immune signaling pathways by deubiquitinating enzymes, and through degradative ubiquitination. It focusses on spatiotemporal regulation of deubiquitinase and E3 ligase activities, mechanisms for re-establishing proteostasis, and degradation through immune-specific feedback mechanisms vs. general protein quality control pathways.

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Section: Ubiquitin As a Versatile Signal To Regulate The Immune Responsementioning

confidence: 99%

Negative Regulation of the Innate Immune Response through Proteasomal Degradation and Deubiquitination

Budroni

Versteeg

2021

Viruses

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“…Due to the fact that lipids are easily designed, synthesized and characterized, they have wide application areas [Zhi et al, 2018, Williams andGrant., 2019]. Many factors on the surface of the nanoparticle used in the calciumphosphate-lipid system can affect blood retention time and organ-specific accumulation [Alexis et al, 2008, Nuti et al, 2018.…”

Section: Lipids and Preventive Dentistrymentioning

confidence: 99%

Lipids and Their Importance in Dentistry

Çibuk¹,

Yarat²

2021

ERD

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Lipids in the structure of cell membranes in the oral environment determine the elasticity, fluidity and permeability of the cell membrane and participate in intercellular transport and signal transduction pathways between the salivary glands and other tissues. Lipids are also important main components of saliva. The properties and number of lipid component in cells and tissues vary according to various physiological and pathological conditions. Identification of lipids, which play a major role in disease states, is used to evaluate the diagnosis and treatment response of diseases. This also applies to various oral diseases. For example, in the presence of chronic periodontititis, caries and calculus, the amount of lipids in saliva increases. Oral surface lipids of pathogenic bacteria such as Porhynomonas gingivalis, one of the main bacteria causing periodontitis, also cause negative effects.

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“…13 Many metal ions such as Ce 4+ , Co 2+ , Co 3+ , Fe 3+ , Ni 2+ , Mo 4+ , Pd 2+ , Zr 4+ and trivalent lanthanides are considered hydrolytic agents. 14,15 Metal-induced RNA cleavage has been used as a structural probing method. 16 Some single-strand nucleic acids can bind certain metal ions and exhibit catalytic activities for DNA or RNA cleavage.…”

Section: Introductionmentioning

confidence: 99%