Metagenomic approaches to understanding phylogenetic diversity in quorum sensing

Kimura, Nobutada

doi:10.4161/viru.27850

Cited by 36 publications

(23 citation statements)

References 100 publications

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“…In other studies, proteins homologous to LuxR and LuxS were found in Desulfovibrio magneticus [74], D. desulfuricans [75], and D. vulgaris [76]. A further mining of the SRB genomes available in the NCBI database also showed that proteins homologous to LuxS AI-2 synthase and the AI-2 receptors (i.e., LuxP and LuxQ) are present in many Desulfovibrio species.…”

Section: Introductionmentioning

confidence: 90%

Quorum Sensing and the Use of Quorum Quenchers as Natural Biocides to Inhibit Sulfate-Reducing Bacteria

2016

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Sulfate-reducing bacteria (SRB) are one of the main protagonist groups of biocorrosion in the seawater environment. Given their principal role in biocorrosion, it remains a crucial task to develop strategies to reduce the abundance of SRBs. Conventional approaches include the use of biocides and antibiotics, which can impose health, safety, and environmental concerns. This review examines an alternative approach to this problem. This is achieved by reviewing the role of quorum sensing (QS) in SRB populations and its impact on the biofilm formation process. Genome databases of SRBs are mined to look for putative QS systems and homologous protein sequences representative of autoinducer receptors or synthases. Subsequently, this review puts forward the potential use of quorum quenchers as natural biocides against SRBs and outlines the potential strategies for the implementation of this approach.

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Section: Introductionmentioning

confidence: 90%

Quorum Sensing and the Use of Quorum Quenchers as Natural Biocides to Inhibit Sulfate-Reducing Bacteria

2016

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“…Poor to moderate antibacterial activity previously observed with these compounds [19] led us to examine their activity on bacterial communication within this study. Bacterial cell-to-cell signaling, so-called quorum sensing (QS), is involved in the regulation of virulence expression and biofilm development, traits that are crucial for pathogenicity and the interaction with colonization of eukaryotic hosts [20,21]. Among gram-negative bacteria, QS is frequently mediated by N-acyl-L-homoserine lactone (AHL) signal molecules [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Diarylheptanoids from Alnus viridis ssp. viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa

et al. 2016

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Diarylheptanoids from the barks of ssp. (green alder) and (black alder) were explored for anti-quorum sensing activity. Chemicals with anti-quorum sensing activity have recently been examined for antimicrobial applications. The anti-quorum sensing activity of the selected diarylheptanoids was determined using two biosensors, namely PAO1 and CV026. Although all of the investigated compounds negatively influenced the motility of PAO1, four were able to inhibit biofilm formation of this human opportunistic pathogen for 40-70 %. Three of the diarylheptanoids (, and ) negatively influenced the biosynthesis of pyocyanin, which is under the control of quorum sensing. Platyphyllenone () and hirsutenone () were able to inhibit the biosynthesis of violacein in CV026, with being able to inhibit the synthesis of both biopigments. Only one of the tested diarylheptanoids () was shown to significantly decrease the production of acyl homoserine lactones (AHL) in PAO1, more specifically, production of the long chain N-(3-oxododecanoyl)-l-HSL. On the other side, four diarylheptanoids (-) significantly reduced the synthesis of 2-alkyl-4-quinolones, part of the quinolone-mediated signaling system. To properly assess therapeutic potential of these compounds, their antiproliferative effect on normal human lung fibroblasts was determined, with doses affecting cell proliferation between 10 and 100 µg/mL. This study confirms that the barks of green and black alders are rich source of phytochemicals with a wide range of biological activities that could further be exploited as natural agents against bacterial contaminations and infections.

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“…This QS mediated multicellular behaviour is evidently a selection pressure and evolution in disguise [7]. The existence of QS systems (QSS) enlightened a galore of processes: bioluminescence, biofilm formation, antibiotic production, nodulation, swarming, conjugation, toxin secretion, exoenzyme secretion, biocorrosion, and virulence factors like siderophores [8][9][10]. This elaborate communication mechanism provides the bacterial population with an advantage of an evolved social behavior [6].…”

Section: Introductionmentioning

confidence: 99%

Potential Emergence of Multi-quorum Sensing Inhibitor Resistant (MQSIR) Bacteria

et al. 2015

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Expression of certain bacterial genes only at a high bacterial cell density is termed as quorum-sensing (QS). Here bacteria use signaling molecules to communicate among themselves. QS mediated genes are generally involved in the expression of phenotypes such as bioluminescence, biofilm formation, competence, nodulation, and virulence. QS systems (QSS) vary from a single in Vibrio spp. to multiple in Pseudomonas and Sinorhizobium species. The complexity of QSS is further enhanced by the multiplicity of signals: (1) peptides, (2) acyl-homoserine lactones, (3) diketopiperazines. To counteract this pathogenic behaviour, a wide range of bioactive molecules acting as QS inhibitors (QSIs) have been elucidated. Unlike antibiotics, QSIs don't kill bacteria and act at much lower concentration than those of antibiotics. Bacterial ability to evolve resistance against multiple drugs has cautioned researchers to develop QSIs which may not generate undue pressure on bacteria to develop resistance against them. In this paper, we have discussed the implications of the diversity and multiplicity of QSS, in acting as an arsenal to withstand attack from QSIs and may use these as reservoirs to develop multi-QSI resistance.

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Metagenomic approaches to understanding phylogenetic diversity in quorum sensing

Cited by 36 publications

References 100 publications

Quorum Sensing and the Use of Quorum Quenchers as Natural Biocides to Inhibit Sulfate-Reducing Bacteria

Quorum Sensing and the Use of Quorum Quenchers as Natural Biocides to Inhibit Sulfate-Reducing Bacteria

Diarylheptanoids from Alnus viridis ssp. viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosa

Potential Emergence of Multi-quorum Sensing Inhibitor Resistant (MQSIR) Bacteria

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