Metabotropic glutamate receptor 5 promotes proliferation of human neural stem/progenitor cells with activation of mitogen-activated protein kinases signaling pathway in vitro

Brain-derived neurotrophic factor increases the motility of a particular N-methyl-d-aspartate /GABA-responsive subset of neural progenitor cells

“…The metabotropic glutamate receptor-induced Ca 2+ response has earlier been identified pharmacologically to be mediated by mGluR5, both in embryonic and postnatal neural progenitors (Castre´n et al, 2005;Ka¨rkka¨inen et al, 2009). The mGluR5 receptors are expressed in neural progenitors in vivo (Di Giorgi-Gerevini et al, 2004) and are of central importance for neurogenesis (Di Giorgi-Gerevini et al, 2004;Baskys et al, 2005;Simonyi et al, 2005;Gandhi et al, 2008;Zhao et al, 2011). BDNF did not significantly affect the distribution of cells responding to DHPG, which is in agreement with the lack of effect on the distribution of GLAST intensity and the length of radial processes.…”

Developmental distribution pattern of metabotropic glutamate receptor 5 in prenatal human hippocampus

“…But these limitations do not influence the conclusion Therefore, mGluR5 mainly regulates the proliferation of neural stem/progenitor cells with MAPK pathway in early development [24] . However, in late development, it mainly takes part in the synaptogenesis, synaptic plasticity and synaptic transmission.…”

“…In contrast to its proliferative effects in the ventral telencephalon, mGluR5 has no such effects on dorsal telencephalon-derived cortical neuroblasts [23] . Studies in our laboratory showed that mGluR5 enhances the proliferation of neural stem cells from human fetal brain along with activation of the mitogen-activated protein kinase (MAPK) signaling pathway [24] .…”

Group I metabotropic glutamate receptor signaling regulates the release of BDNF and LIF by neural stem cells

“…The effects of glutamate are mediated both by ionotropic receptors/channels (iGluRs) [8] and by metabotropic receptors (mGluRs) [9]. The activation of group I mGluRs (composed of mGluR1 and mGluR5) via the administration of specific agonists induces the proliferation of rodent embryonic stem cells and NSCs, as well as human NSCs, both in vitro and in vivo [10] [11] [12] [13].…”