Brain-derived neurotrophic factor increases the motility of a particular N-methyl-d-aspartate /GABA-responsive subset of neural progenitor cells

Jansson, Linda C.; Louhivuori, Lauri; Wigren, Henna-Kaisa; Nordström, Tommy; Louhivuori, Verna; Castrén, Maija; Åkerman, Karl E.O.

doi:10.1016/j.neuroscience.2012.08.038

Cited by 28 publications

(40 citation statements)

References 49 publications

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“…Two different inbred strains of mice Friends virus B (FVB) and 129SvJ/ C57Bl6/N (C57) were used in this study. We have extensively characterized the neural progenitor calcium responses from FVB mice in previous studies [7,[21][22][23], and thus, our initial characterizations in this study were done with this strain. Our interest in elucidating the function of TRPC channels in neural progenitor migration as well as the current lack of specific channel blockers for the TRPCs led us to use TRPCdeficient C57 mice.…”

Section: Micementioning

confidence: 99%

“…Calcium imaging was performed as described previously [22,23,26]. For the experiments, 20-30 neurospheres were plated on poly-dl-ornithine-coated 25-mm cover glasses and differentiated for the indicated time periods.…”

Section: Calcium Imagingmentioning

confidence: 99%

“…Differentiating cells were fixed and immunostained as described previously [23]. Primary antibodies used were the mouse monoclonal anti-microtubule-associated protein (MAP)-2 (MAB364; Millipore) and the rabbit polyclonal anti-excitatory amino acid transporter 1, also known as glial glutamate-aspartate transporter (GLAST, ab416; Abcam).…”

Section: Immunocytochemistrymentioning

confidence: 99%

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Transient Receptor Potential Channels and Their Role in Modulating Radial Glial–Neuronal Interaction: A Signaling Pathway Involving mGluR5

Louhivuori

Jansson

Turunen

et al. 2015

Stem Cells and Development

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The guidance of developing neurons to the right position in the central nervous system is of central importance in brain development. Canonical transient receptor potential (TRPC) channels are thought to mediate turning responses of growth cones to guidance cues through fine control of calcium transients. Proliferating and 1-to 5-day-differentiated neural progenitor cells (NPCs) showed expression of Trpc1 and Trpc3 mRNA, while Trpc4-7 was not clearly detected. Time-lapse imaging showed that the motility pattern of neuronal cells was phasic with bursts of rapid movement ( > 60 mm/h), changes in direction, and intermittent slow phases or stallings ( < 40 mm/ h), which frequently occurred in close contact with radial glial processes. Genetic interference with the TRPC3 and TRPC1 channel enhanced the motility of NPCs (burst frequency/stalling frequency). TRPC3-deficient cells or cells treated with the TRPC3 blocker pyr3 infrequently changed direction and seldom contacted radial glial processes. TRPC channels are also activated by group I metabotropic glutamate receptors (mGluR1 and mGluR5). As shown here, pyr3 blocked the calcium response mediated through mGluR5 in radial glial processes. Furthermore, 2-methyl-6-(phenylethynyl)pyridine, a blocker of mGluR5, affected the motility pattern in a similar way as TRPC3/6 double knockout or pyr3. The results suggest that radial glial cells exert attractant signals to migrating neuronal cells, which alter their motility pattern. Our results suggest that mGluR5 acting through TRPC3 is of central importance in radial glial-mediated neuronal guidance.

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Section: Micementioning

confidence: 99%

Section: Calcium Imagingmentioning

confidence: 99%

Section: Immunocytochemistrymentioning

confidence: 99%

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Transient Receptor Potential Channels and Their Role in Modulating Radial Glial–Neuronal Interaction: A Signaling Pathway Involving mGluR5

Louhivuori

Jansson

Turunen

et al. 2015

Stem Cells and Development

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“…BDNF is a critical component of synaptic maturation, synaptic plasticity, and neurogenesis (37)(38)(39)(40). FXS can be classified as a disorder of the synapse (14,41,42).…”

Section: Serotonin and Up-regulation Of Brain Derived Neurotropic Facmentioning

confidence: 99%

Serotonin dysregulation in Fragile X Syndrome: implications for treatment

Hanson

Hagerman

2014

IRDR

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“…11 Substantial evidence has shown that NFs also interact with neurotransmitter systems. 12,13 Their effects on dopaminergic neuronal function in particular may be a critical path for drug addiction because the dopamine (DA) system is a key component of the brain circuitry of motivation and reward. [14][15][16] Preclinical investigations have demonstrated that cocaine administration can increase the levels of BDNF in rodents.…”

Section: Introductionmentioning

confidence: 99%

Neurotrophic factors in women with crack cocaine dependence during early abstinence: the role of early life stress

Viola

Tractenberg

Levandowski

et al. 2014

J Psychiatry Neurosci

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Brain-derived neurotrophic factor increases the motility of a particular N-methyl-d-aspartate /GABA-responsive subset of neural progenitor cells

Cited by 28 publications

References 49 publications

Transient Receptor Potential Channels and Their Role in Modulating Radial Glial–Neuronal Interaction: A Signaling Pathway Involving mGluR5

Transient Receptor Potential Channels and Their Role in Modulating Radial Glial–Neuronal Interaction: A Signaling Pathway Involving mGluR5

Serotonin dysregulation in Fragile X Syndrome: implications for treatment

Neurotrophic factors in women with crack cocaine dependence during early abstinence: the role of early life stress

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