Metabonomics study of urine from Sprague–Dawley rats exposed to Huang-yao-zi using 1H NMR spectroscopy

Liu, Yanru; Huang, Renfang; Liu, Lijun; Peng, Jiangnan; Xiao, Bingkun; Yang, Jianyun; Miao, Zhenchun; Huang, Haoliang

doi:10.1016/j.jpba.2009.12.026

Cited by 61 publications

(43 citation statements)

References 20 publications

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“…Metabolomic profiles of numerous hepatotoxins in laboratory animals have been described, and include hydrazine [117], bromobenzene [118, 119], methapyrilene [120], methylenedianiline [121], D-galactosamine [121–123], clofibrate [121], allyl formate [124], the anti-HBV compound Bay41-4109 [125], paracetamol [126–133], isoniazid [134, 135], carbon tetrachloride [131, 136–138], α-naphthylisothiocyanate [137], perfluorododecanoic acid [139], valproate [140], Huang-yao-zi [141], dimethylnitrosamine [142], polychlorinated biphenyls [143, 144], 2,3,7,8-tetrachlorodibenzo- p -dioxin [143], methamphetamine [145], (+)-usnic acid [146], pentamethychromanol [147] and methotrexate [131]. Detailed analysis of these drug-induced liver injury (DILI) studies falls beyond the scope of this review.…”

Section: The Metabolomic Window Into Acute Liver Toxicity In Animal Mmentioning

confidence: 99%

The metabolomic window into hepatobiliary disease

Beyoğlu¹,

Idle²

2013

Journal of Hepatology

196

198

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Summary The emergent discipline of metabolomics has attracted considerable research effort in hepatology. Here we review the metabolomic data for nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), cirrhosis, hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), alcoholic liver disease (ALD), hepatitis B and C, cholecystitis, cholestasis, liver transplantation and acute hepatotoxicity in animal models. A metabolomic window has permitted a view into the changing biochemistry occurring in the transitional phases between a healthy liver and hepatocellular carcinoma or cholangiocarcinoma. Whether provoked by obesity and diabetes, alcohol use or oncogenic viruses, the liver develops a core metabolomic phenotype (CMP) that involves dysregulation of bile acid and phospholipid homeostasis. The CMP commences at the transition between the healthy liver (Phase 0) and NAFLD/NASH, ALD or viral hepatitis (Phase 1). This CMP is maintained in the presence or absence of cirrhosis (Phase 2) and whether or not either HCC or CCA (Phase 3) develop. Inflammatory signalling in the liver triggers the appearance of the CMP. Many other metabolomic markers distinguish between Phases 0, 1, 2 and 3. A metabolic remodelling in HCC has been described but metabolomic data from all four Phases demonstrate that the Warburg shift from mitochondrial respiration to cytosolic glycolysis foreshadows HCC and may occur as early as Phase 1. The metabolic remodelling also involves an upregulation of fatty acid β-oxidation, also beginning in Phase 1. The storage of triglycerides in fatty liver provides high energy-yielding substrates for Phases 2 and 3 of liver pathology. The metabolomic window into hepatobiliary disease sheds new light on the systems pathology of the liver.

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Section: The Metabolomic Window Into Acute Liver Toxicity In Animal Mmentioning

confidence: 99%

The metabolomic window into hepatobiliary disease

Beyoğlu¹,

Idle²

2013

Journal of Hepatology

196

198

View full text Add to dashboard Cite

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“…2. The endogenous metabolites were identified according to published reports (Bollard et al, 2001;Nicholls et al, 2001;Wang et al, 2005;Li et al, 2008;Sun et al, 2009;An et al, 2010;Liu et al, 2010), and were labeled in the spectra. In this study, multivariate analysis technique was used to visualize and detect any possible subtle change due to CUMS treatment.…”

Section: Analysis Of Urine Samples From Control Group and Model Groupmentioning

confidence: 99%

“…NMR spectrometry can provide rapid, non-destructive and high-through methods, requiring minimal sample preparation (Li et al, 2008). And NMR spectra of a biofluid are rich in extremely complex information relating to the concentration of these metabolites in the sample (Liu et al, 2010). Based on the reasons above, the applications of metabonomics method based on NMR in this field are increasing.…”

Section: Introductionmentioning

confidence: 99%

Antidepressant-like effects of the fractions of Xiaoyaosan on rat model of chronic unpredictable mild stress

Zhou

et al. 2011

Journal of Ethnopharmacology

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“…As we all know, NMR spectroscopy (Liu et al, 2010), LC-MS (Sangster et al, 2007), CE-MS (Ullsten et al, 2006) and GC-MS (Yu et al, 2007) have been widely used in metabonomics studies. Among them, GC-MS has been proved of high selectivity and reproducibility.…”

Section: Introductionmentioning

confidence: 99%

A plasma metabonomic investigation into the intervention of volatile oil of Magnolia biondii Pamp on rat model of acute inflammation

et al. 2011

Journal of Ethnopharmacology

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Metabonomics study of urine from Sprague–Dawley rats exposed to Huang-yao-zi using 1H NMR spectroscopy

Cited by 61 publications

References 20 publications

The metabolomic window into hepatobiliary disease

The metabolomic window into hepatobiliary disease

Antidepressant-like effects of the fractions of Xiaoyaosan on rat model of chronic unpredictable mild stress

A plasma metabonomic investigation into the intervention of volatile oil of Magnolia biondii Pamp on rat model of acute inflammation

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