Antidepressant-like effects of the fractions of Xiaoyaosan on rat model of chronic unpredictable mild stress

Dynamic analysis of the endogenous metabolites in depressed patients treated with TCM formula Xiaoyaosan using urinary 1H NMR-based metabolomics

“…Creatinine, a breakdown product of creatine phosphate in muscle, is transferred to the kidneys by blood, where it is eliminated from the body through glomerular filtration and partial tubular excretion. It originates from the slow spontaneous degradation of creatine-phosphate, while creatinephosphate is always viewed as a "battery" that stores the energy of excess ATP (Zhou et al, 2011). Generally, in this study, there was good agreement with the variation of these metabolites in depressed patients or animal models in previous studies.…”

Antidepressant-like effect of the extracted of Kai Xin San, a traditional Chinese herbal prescription, is explained by modulation of the central monoaminergic neurotransmitter system in mouse

“…The antidepressant effect of herbs has been paid more and more attention because of increasing incidence of depression and predominance of traditional herbs in therapy (Wong et al, 2004;Sanchez-Mateo et al, 2005;Zhou et al, 2011). As for any antidepressant screening test, essential requirement is accurate prediction about antidepressant activity, with such characteristics as cheapness, robustness, reliability and easy to use (Mitchell, 2005).…”

Anti-depressant-like effect of peony: a mini-review

“…When tested in a rat model of chronic unpredictable mild stress (CUMS), the drug-treated animals displayed urinary metabolomic pattern similar to that of the normal controls (Dai et al, 2010). More recently, the petroleum ether fraction of Xiaoyao-San preparation was also reported to be active in CUMS-rats (Zhou et al, 2011).…”