Metabonomics of Human Colorectal Cancer: New Approaches for Early Diagnosis and Biomarker Discovery

Ni, Yan; Xie, Guoxiang; Wang, Jia

doi:10.1021/pr500443c

Cited by 133 publications

(95 citation statements)

References 81 publications

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“…It is a powerful analytical platform that allows for the assessment of global metabolic profiles in easily accessible biofluids and biomarker discovery in order to distinguish between diseased and non-diseased status information [8] as well as for the evaluation of drug toxicity and gene function [9]. A number of new analytical technologies have been employed for metabolomics analysis, including 1 H-NMR [10], ultra-high-performance liquid chromatography quadrupole-time-of-flight/high-sensitivity mass spectrometry (UPLC-Q-TOF/HSMS) [11], UPLC-electrospray ionization/MS (UPLC-ESI/MS) [12], gas chromatography/MS [13] and others.…”

Section: Introductionmentioning

confidence: 99%

Serum Metabolomic Characteristics of Patients with Liver Cirrhotic Ascites

Yang¹,

Zheng²,

Feng³

et al. 2015

Integr Med Int

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Chronic hepatitis B is a common and frequently encountered disease in our country, the final outcome of which develops into liver cirrhosis and primary liver cancer.It was the aim of this study to provide a theoretical basis for the early diagnosis and treatment of liver cirrhosis. Ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS) is used to analyze endogenous bioactive substance change in healthy controls and patients with liver cirrhotic ascites. A metabolic fingerprint spectrum was established for the analysis. The results show that metabolic profiling of the serum indicates significant differences between the controls and the patients. Except for the tyrosine content which was decreased in the serum, the other 12 amino acids and 8 conjugated bile acids were significantly increased compared to controls (p < 0.01). Additionally, the 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) of serum were significantly decreased in the patients with liver cirrhotic ascites. In conclusion, the lysophosphatidylcholines C18:0, C18:2 and C16:1 are potential biomarkers. Moreover, the bile acid metabolism, amino acid metabolism and 5-HT as well as 5-HIAA metabolites are significantly changed in patients with cirrhotic ascites. These endogenous metabolites are potential biomarkers used for the diagnosis and treatment of liver fibrosis and cirrhosis.

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Section: Introductionmentioning

confidence: 99%

Serum Metabolomic Characteristics of Patients with Liver Cirrhotic Ascites

Yang¹,

Zheng²,

Feng³

et al. 2015

Integr Med Int

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“…Long-term examination of serum tumor markers may help identify novel tumor markers with superior efficacy [39][40][41]. Even if novel markers are found, it is still comparable for THI under the unified system.…”

Section: Discussionmentioning

confidence: 99%

A system for tumor heterogeneity evaluation and diagnosis based on tumor markers measured routinely in the laboratory

Liu

Rixv

Zhou

2015

Clinical Biochemistry

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“…Today, thanks to metabolomics (7), one is able to define prognostic, early and diagnostic, and late biomarkers of diseases (8), which is an important breakthrough for secondary prevention. This evidently applies to dietrelated chronic diseases like obesity (9), type 2 diabetes (10), cardiovascular diseases (11) and cancers (12). But to the best of our knowledge, the healthy state remains to be defined or characterized via metabolomics.…”

Section: How Is Defined a Healthy Sate? The Current Paradigmsmentioning

confidence: 99%

The healthy core metabolism: A new paradigm for primary preventive nutrition

Fardet

Rock

2016

The Journal of nutrition, health and aging

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Research in preventive nutrition aims at elucidating mechanism by which our diet helps us to remain in good health through optimal physiological functions. However, despite decades of accumulated data in human nutrition and regular subsequent nutritional recommendations, obesity and type 2 diabetes epidemics continue to progress worldwide each year leading to a regular decrease of the Healthy Life Years, notably in Western countries. Such a paradox may be explained by the Nutrition Transition, the extreme application of the reductionist paradigm in nutrition research, the lack of nutritional education and a too strong focus on curative nutrition in at risk/ill subjects. In this position paper, we hypothesized that researchers should focus more on healthy subjects, from birth until maturity. Rather than exploring what differentiates healthy and at risk/ill subjects, we propose to thoroughly study what characterizes a healthy state and its underlying metabolism. We define it as the Healthy Core Metabolism which remains stable whatever energy inputs (diets) and outputs (exercise), genetic background and external/internal stress, e.g., temporary illnesses. As a basis for Healthy Core Metabolism investigation, we observed that main physiological and ubiquitous functions of human organism, i.e., the neuro-vasculo-sarco-osteoporotic system, tend to follow a concave curve with common phases of growth, optimum, and decline. Finally, we hypothesized that true primary preventive nutrition should focus on the growth phase to reach the maximum capital of a given physiological function so that - whatever the further decline -, Healthy Life Years may approach or coincide with theoretical Life Expectancy.

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Metabonomics of Human Colorectal Cancer: New Approaches for Early Diagnosis and Biomarker Discovery

Cited by 133 publications

References 81 publications

Serum Metabolomic Characteristics of Patients with Liver Cirrhotic Ascites

Serum Metabolomic Characteristics of Patients with Liver Cirrhotic Ascites

A system for tumor heterogeneity evaluation and diagnosis based on tumor markers measured routinely in the laboratory

The healthy core metabolism: A new paradigm for primary preventive nutrition

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