Metabolomics reveals the mechanism of polyethylene microplastic toxicity to Daphnia magna

Wang, Peng; Li, Qin‐Qin; Jin, Hui; Xiang, Qian-Qian; Yan, Hui; Chen, Li Qiang

doi:10.1016/j.chemosphere.2022.135887

Cited by 21 publications

(5 citation statements)

References 49 publications

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“…Pitt et al (2018) found that exposure of zebrafish embryos to polystyrene microplastics resulted in the translocation of microplastic particles into the heart and a subsequent decrease in heart rate. Similarly, Wang et al (2022) found that exposure of Daphnia magna to polyethylene microplastics of 20 and 30 mm size resulted in a suppressed heart rate. The study also revealed that different particle sizes had varying toxic effects on Daphnia magna, with larger microplastic sizes causing the degradation of amino acid metabolites.…”

Section: Biological Effect On the Lung Mechanism Referencementioning

confidence: 87%

Microplastic sources, formation, toxicity and remediation: a review

et al. 2023

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Microplastic pollution is becoming a major issue for human health due to the recent discovery of microplastics in most ecosystems. Here, we review the sources, formation, occurrence, toxicity and remediation methods of microplastics. We distinguish ocean-based and land-based sources of microplastics. Microplastics have been found in biological samples such as faeces, sputum, saliva, blood and placenta. Cancer, intestinal, pulmonary, cardiovascular, infectious and inflammatory diseases are induced or mediated by microplastics. Microplastic exposure during pregnancy and maternal period is also discussed. Remediation methods include coagulation, membrane bioreactors, sand filtration, adsorption, photocatalytic degradation, electrocoagulation and magnetic separation. Control strategies comprise reducing plastic usage, behavioural change, and using biodegradable plastics. Global plastic production has risen dramatically over the past 70 years to reach 359 million tonnes. China is the world's top producer, contributing 17.5% to global production, while Turkey generates the most plastic waste in the Mediterranean region, at 144 tonnes per day. Microplastics comprise 75% of marine waste, with land-based sources responsible for 80–90% of pollution, while ocean-based sources account for only 10–20%. Microplastics induce toxic effects on humans and animals, such as cytotoxicity, immune response, oxidative stress, barrier attributes, and genotoxicity, even at minimal dosages of 10 μg/mL. Ingestion of microplastics by marine animals results in alterations in gastrointestinal tract physiology, immune system depression, oxidative stress, cytotoxicity, differential gene expression, and growth inhibition. Furthermore, bioaccumulation of microplastics in the tissues of aquatic organisms can have adverse effects on the aquatic ecosystem, with potential transmission of microplastics to humans and birds. Changing individual behaviours and governmental actions, such as implementing bans, taxes, or pricing on plastic carrier bags, has significantly reduced plastic consumption to 8–85% in various countries worldwide. The microplastic minimisation approach follows an upside-down pyramid, starting with prevention, followed by reducing, reusing, recycling, recovering, and ending with disposal as the least preferable option.

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Section: Biological Effect On the Lung Mechanism Referencementioning

confidence: 87%

Microplastic sources, formation, toxicity and remediation: a review

et al. 2023

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“…For example, zebrafish Danio rerio has been exposed for 30 days to 44 nm PS NPs (1, 10, and 100 μg L −1 ) 50 and for 96 h to ∼190 nm PE NPs (5 × 10 5 μg L −1 ). 51 Additionally, D. magna has previously been exposed to MPs and NPs, for example, 24 h exposure to 20 μm and 30 μm PE MPs (2–6 × 10 4 μg L −1 ), 26 5 days exposure to 52 nm PS NPs (5 × 10 3 μg L −1 ), 34 and 21 days exposure to ∼71 nm PS NPs (500–2 × 10 3 μg L −1 ). 52…”

Section: Discussionmentioning

confidence: 99%

“…59,60 Additionally, a short (24 h) exposure to 20 μm and 30 μm PE MPs have been shown to significantly interfere with energy metabolism in D. magna . 26…”

Section: Discussionmentioning

confidence: 99%

“…Metabolomics have previously been used to study the metabolic responses of D. magna induced by various toxicants, such as silver (Ag) nitrate and Ag NPs, 25 PE MPs, 26 pharmaceuticals, 27 cadmium, 28 arsenic, copper, lithium, 29 insecticides, or industrial chemicals. 30,31 It has been shown that released Ag + induced disturbance in energy metabolism and oxidative stress, 25 PE MPs downregulated phosphatidylcholine and upregulated phosphatidylethanolamine, as well as induced the degradation of amino acids, 26 copper and lithium altered production of neurotransmitters and impaired energy metabolism 29 to D. magna .…”

Section: Introductionmentioning

confidence: 99%

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Metabolomics-based analysis in Daphnia magna after exposure to low environmental concentrations of polystyrene nanoparticles

Kelpsiene

Cedervall

Malmendal

2023

Environ. Sci.: Nano

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“…Therefore, there is a need to use targeted MS/MS techniques for the quantification of endogenous metabolites in environmentally relevant organisms or samples of limited mass, such as fish mucus [ 18 ], in addition to metabolic profiling by NMR spectroscopy [ 19 , 20 ]. A particular group of metabolites of interest include free amino acids which are commonly used to assess changes in the metabolic profile of various organisms [ 4 ], including earthworms [ 21 , 22 , 23 , 24 ], Daphnia [ 25 , 26 , 27 , 28 ], and various fish [ 29 , 30 , 31 , 32 , 33 , 34 , 35 ] and plant species [ 10 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ]. Amino acids are commonly analyzed because changes in their concentrations can be used to examine mechanisms such as oxidative stress, disruptions to energy metabolism and protein degradation.…”

Section: Introductionmentioning

confidence: 99%

Cross-Platform Comparison of Amino Acid Metabolic Profiling in Three Model Organisms Used in Environmental Metabolomics

et al. 2023

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Environmental metabolomics is a promising approach to study pollutant impacts to target organisms in both terrestrial and aquatic environments. To this end, both nuclear magnetic resonance (NMR)- and mass spectrometry (MS)-based methods are used to profile amino acids in different environmental metabolomic studies. However, these two methods have not been compared directly which is an important consideration for broader comparisons in the environmental metabolomics field. We compared the quantification of 18 amino acids in the tissue extracts of Daphnia magna, a common model organism used in both ecotoxicology and ecology, using both 1H NMR spectroscopy and liquid chromatography with tandem MS (LC-MS/MS). 1H NMR quantification of amino acids agreed with the LC-MS/MS quantification for 17 of 18 amino acids measured. We also tested both quantitative methods in a D. magna sub-lethal exposure study to copper and lithium. Again, both NMR and LC-MS/MS measurements showed agreement. We extended our analyses with extracts from the earthworm Eisenia fetida and the plant model Nicotiana tabacum. The concentrations of amino acids by both 1H NMR and LC-MS/MS, agreed and demonstrated the robustness of both techniques for quantitative metabolomics. These findings demonstrate the compatibility of these two analytical platforms for amino acid profiling in environmentally relevant model organisms and emphasizes that data from either method is robust for comparisons across studies to further build the knowledge base related to pollutant exposure impacts and toxic responses of diverse environmental organisms.

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Metabolomics reveals the mechanism of polyethylene microplastic toxicity to Daphnia magna

Cited by 21 publications

References 49 publications

Microplastic sources, formation, toxicity and remediation: a review

Microplastic sources, formation, toxicity and remediation: a review

Metabolomics-based analysis in Daphnia magna after exposure to low environmental concentrations of polystyrene nanoparticles

Cross-Platform Comparison of Amino Acid Metabolic Profiling in Three Model Organisms Used in Environmental Metabolomics

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