volume 8, issue 1, P77-86 2016
DOI: 10.18632/aging.100874
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Jonas Zierer, Gabi Kastenmüller, Karsten Suhre, Christian Gieger, Veryan Codd, Pei-Chien Tsai, Jordana Bell, Annette Peters, Konstantin Strauch, Holger Schulz, Stephan Weidinger, Robert P. Mohney, Nilesh J. Samani, Tim Spector et al.

Abstract: Leukocyte telomere length (LTL) is considered one of the most predictive markers of biological aging. The aim of this study was to identify novel pathways regulating LTL using a metabolomics approach. To this end, we tested associations between 280 blood metabolites and LTL in 3511 females from TwinsUK and replicated our results in the KORA cohort. We furthermore tested significant metabolites for associations with several aging-related phenotypes, gene expression markers and epigenetic markers to investigate …

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