Metabolomics of alcoholic liver disease: a clinical discovery study

Abstract

Metabolomics is a powerful technology which shows great potential in biomarker discovery. A total of three urinary differential metabolites were identified, and more important, these biomarkers may be sensitive to early diagnosis of ALD disease.

Exploration of metabolite signatures using high-throughput mass spectrometry coupled with multivariate data analysis

“…30 Currently, the application of metabolomics to urine samples has been successful in nding potential biomarkers for diseases. [35][36][37][38][39] Our ndings have dened a panel of molecules whose levels are altered in the urine of RA patients. The urine biomarkers identied in this study exhibited satisfactory diagnostic performance.…”

Characterization of chemical constituents and absorbed components, screening the active components of gelanxinning capsule and an evaluation of therapeutic effects by ultra‐high performance liquid chromatography with quadrupole time of flight mass spectrometry

“…Lipids metabolism makes metabolomics a more promising way to explore these types of diseases as the core issues in CVD. Application of metabolomics in clinical research has provided the chance to obtain new insights into metabolic change and mechanism [62][63][64]. A large amount of information bringing about by metabolomics indicated that these approaches will open a new perspective on disease processes and eventually transit from theory to clinical applications [65][66][67][68][69][70].…”

High-throughput metabolomics enables metabolite biomarkers and metabolic mechanism discovery of fish in response to alkalinity stress

“…The highthroughput metabolomics can provide the tool for further investigation of the metabolic mechanism. [20][21][22][23][24][25][26][27][28][29][30][31] Therefore, we examined the long-term effects of alkalinity stress on the CC. The metabolic proles are studied by top-down thermometric analysis.…”