Metabolomics as a powerful tool to decipher the biological effects of environmental contaminants in humans

Bonvallot, Nathalie; David, Arthur; Chalmel, Frédéric; Chevrier, Cécile; Cordier, Sylvaine; Cravedi, Jean‐Pierre; Zalko, Daniel

doi:10.1016/j.cotox.2017.12.007

Cited by 37 publications

(29 citation statements)

References 41 publications

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“…An exhaustive review by Bonvallot et al (187) revealed that in addition to PM 2.5 , diverse groups of toxicants such as PAHs, heavy metals, organochlorine compounds, and plasticizers affect common metabolic pathways. Ambient and occupational exposures to these toxicants lead to disruption of signaling pathways associated with inflammation and oxidative stress, which are drivers of atherosclerosis and metabolic disorders (188).…”

Section: Relevance Of Metabolomics In Chemical Exposure-induced Cvdmentioning

confidence: 99%

Use of an Exposome Approach to Understand the Effects of Exposures From the Natural, Built, and Social Environments on Cardio-Vascular Disease Onset, Progression, and Outcomes

Juárez

Hood

Song

et al. 2020

Front. Public Health

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Obesity, diabetes, and hypertension have increased by epidemic proportions in recent years among African Americans in comparison to Whites resulting in significant adverse cardiovascular disease (CVD) disparities. Today, African Americans are 30% more likely to die of heart disease than Whites and twice as likely to have a stroke. The causes of these disparities are not yet well-understood. Improved methods for identifying underlying risk factors is a critical first step toward reducing Black:White CVD disparities. This article will focus on environmental exposures in the external environment and how they can lead to changes at the cellular, molecular, and organ level to increase the personal risk for CVD and lead to population level CVD racial disparities. The external environment is defined in three broad domains: natural (air, water, land), built (places you live, work, and play) and social (social, demographic, economic, and political). We will describe how environmental exposures in the natural, built, and social environments "get under the skin" to affect gene expression though epigenetic, pan-omics, and related mechanisms that lead to increased risk for adverse CVD health outcomes and population level disparities. We also will examine the important role of metabolomics, proteomics, transcriptomics, genomics, and epigenomics in understanding how exposures in the natural, built, and social environments lead to CVD disparities with implications for clinical, public health, and policy interventions. In this review, we apply an exposome approach to Black:White CVD racial disparities. The exposome is a measure of all the exposures of an individual across the life course and the relationship of those exposures to health effects. The exposome represents the totality of exogenous (external) and endogenous (internal) exposures from conception onwards, simultaneously distinguishing, characterizing, and quantifying etiologic, mediating, moderating, and co-occurring risk and protective factors and their relationship to disease. Specifically, it assesses the biological mechanisms and underlying pathways through which chemical and non-chemical environmental Juarez et al. The Exposome and Cardiovascular Disease exposures are associated with CVD onset, progression and outcomes. The exposome is a promising approach for understanding the complex relationships among environment, behavior, biology, genetics, and disease phenotypes that underlie population level, Black: White CVD disparities.

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Section: Relevance Of Metabolomics In Chemical Exposure-induced Cvdmentioning

confidence: 99%

Use of an Exposome Approach to Understand the Effects of Exposures From the Natural, Built, and Social Environments on Cardio-Vascular Disease Onset, Progression, and Outcomes

Juárez

Hood

Song

et al. 2020

Front. Public Health

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“…As a non-driven approach, it is intended to cover the entire metabolome without prior hypothesis, providing more comprehensive information on the MoA and consequent adverse effects of chemicals. Although still limited, several epidemiological studies, mainly focused on occupational and environmental exposures, have reported the discovery of effect biomarkers that are relevant in hazard identification through the application of non-targeted metabolomics [99]. Duan et al…”

Section: Human Metabolomics For Hazard Identificationmentioning

confidence: 99%

Metabolomics in chemical risk analysis – A review

Hernández‐Mesa

Bizec

2021

Analytica Chimica Acta

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Food safety has become a major issue worldwide and, in particular, detecting the presence of toxins, contaminants or residues of chemical substances along the food chain and in fine in foods constitutes a strong consumers demand. In general, all these substances and the corresponding metabolites of interest are analyzed using efficient targeted methodologies. However, in some cases these targeted approaches do not allow the detection of emerging compounds or practices, and therefore new approaches and strategies are required. Thus, the study of physiological perturbations induced by exposure to a given chemical substance has emerged as an interesting alternative approach to apply in chemical food safety.This review focuses on describing significant applications of metabolomics in the field of risk analysis from a chemical food safety perspective. The different risk assessment steps, including hazard identification, doseresponse assessment and exposure assessment, and risk management are addressed through various examples to illustrate that such an approach is fit-for-purpose and meets the expectations and requirements of chemical risk analysis. It can be considered as an innovative tool for predicting the probable occurrence and nature of risks, while addressing the current challenges of chemical risk analysis (e.g. replacement, reduction and refinement (3R) of animal testing, effects of exposure to chemical mixtures at low doses, etc.), and with the aim of responding to global food safety issues and anticipating human health problems.

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“…Due to their ubiquity in the environment, xenometabolites may also bind to NMs, forming part of their acquired eco-corona, the term used to describe the biomolecular coating acquired by NMs in the environment. [28][29][30] These can include molecules such as polyaromatic hydrocarbons, pharmaceuticals not removed by wastewater treatment plants or chemicals used in agriculture and their associated breakdown products or metabolites. Many of these xenobiotics are known to still be biologically active in the environment and have been demonstrated to affect reproductive behavior and neurochemistry of fish to name just a single organism.…”

Section: Introductionmentioning

confidence: 99%

The rise of the nanomaterial metabolite corona, and emergence of the complete corona

Chetwynd

Lynch

2020

Environ. Sci.: Nano

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Metabolomics as a powerful tool to decipher the biological effects of environmental contaminants in humans

Cited by 37 publications

References 41 publications

Use of an Exposome Approach to Understand the Effects of Exposures From the Natural, Built, and Social Environments on Cardio-Vascular Disease Onset, Progression, and Outcomes

Use of an Exposome Approach to Understand the Effects of Exposures From the Natural, Built, and Social Environments on Cardio-Vascular Disease Onset, Progression, and Outcomes

Metabolomics in chemical risk analysis – A review

The rise of the nanomaterial metabolite corona, and emergence of the complete corona

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