Metabolomics approach to explore the effects of Kai-Xin-San on Alzheimer’s disease using UPLC/ESI-Q-TOF mass spectrometry

Chu, Hang; Zhang, Aihua; Han, Ying; Lu, Shengwen; Kong, Ling; Han, Jinwei; Liu, Zhidong; Sun, Hui; Wang, Xijun

doi:10.1016/j.jchromb.2016.02.007

Cited by 101 publications

(69 citation statements)

References 38 publications

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“…), Polygalae Radix (dried root of Polygala tenuifolia Willd. ), Poria, and Acori Tatarinowii Rhizoma (dried rhizoma of Acortw tatarinowii Schott), is mainly used to treat neurasthenia and Alzheimer's disease (Liu et al, ; Chu et al, ). Wang et al () applied a ultra‐high performance liquid chromatography‐quadrupole time of flight mass spectrometry (UHPLC‐Q‐TOF MS) method to screen the effective chemical constituents of Kaixin San in vitro and in vivo .…”

Section: Herbal Ingredients: Current Research Applications and Emermentioning

confidence: 99%

Novel applications of mass spectrometry‐based metabolomics in herbal medicines and its active ingredients: Current evidence

Wang

Ren

Zhang

et al. 2019

Mass Spectrometry Reviews

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Current evidence shows that herbal medicines could be beneficial for the treatment of various diseases. However, the complexities present in chemical compositions of herbal medicines are currently an obstacle for the progression of herbal medicines, which involve unclear bioactive compounds, mechanisms of action, undetermined targets for therapy, non‐specific features for drug metabolism, etc. To overcome those issues, metabolomics can be a great to improve and understand herbal medicines from the small‐molecule metabolism level. Metabolomics could solve scientific difficulties with herbal medicines from a metabolic perspective, and promote drug discovery and development. In recent years, mass spectrometry‐based metabolomics was widely applied for the analysis of herbal constituents in vivo and in vitro. In this review, we highlight the value of mass spectrometry‐based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, and to enhance their biomedical value in biomedicine, to shed light on the aid that mass spectrometry‐based metabolomics can offer to the investigation of its active ingredients, especially, to link phytochemical analysis with the assessment of pharmacological effect and therapeutic potential. © 2019 Wiley Periodicals, Inc. Mass Spec Rev

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Section: Herbal Ingredients: Current Research Applications and Emermentioning

confidence: 99%

Novel applications of mass spectrometry‐based metabolomics in herbal medicines and its active ingredients: Current evidence

Wang

Ren

Zhang

et al. 2019

Mass Spectrometry Reviews

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100

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“…As an important part of systemic biology, metabolomics is a front subject in the field of medical research272829. It can represent the pathophysiological changes of integrated living systems which are caused by endogenous or exogenous factors303132.…”

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confidence: 99%

Screening the active compounds of Phellodendri Amurensis cortex for treating prostate cancer by high-throughput chinmedomics

Zhang

Wang

et al. 2017

Sci Rep

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Screening the active compounds of herbal medicines is of importance to modern drug discovery. In this work, an integrative strategy was established to discover the effective compounds and their therapeutic targets using Phellodendri Amurensis cortex (PAC) aimed at inhibiting prostate cancer as a case study. We found that PAC could be inhibited the growth of xenograft tumours of prostate cancer. Global constituents and serum metabolites were analysed by UPLC-MS based on the established chinmedomics analysis method, a total of 54 peaks in the spectrum of PAC were characterised in vitro and 38 peaks were characterised in vivo. Among the 38 compounds characterised in vivo, 29 prototype components were absorbed in serum and nine metabolites were identified in vivo. Thirty-four metabolic biomarkers were related to prostate cancer, and PAC could observably reverse these metabolic biomarkers to their normal level and regulate the disturbed metabolic profile to a healthy state. A chinmedomics approach showed that ten absorbed constituents, as effective compounds, were associated with the therapeutic effect of PAC. In combination with bioactivity assays, the action targets were also predicted and discovered. As an illustrative case study, the strategy was successfully applied to high-throughput screening of active compounds from herbal medicine.

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“…[161][162][163][164][165][166][167][168][169] The latest advances in novel MS techniques have greatly improved the progression of metabolomics over the past decade (Fig. 10).…”

Section: -160mentioning

confidence: 99%

Advances in mass spectrometry-based metabolomics for investigation of metabolites

et al. 2018

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Metabolomics is the systematic study of all the metabolites present within a biological system, which consists of a mass of molecules, having a variety of physical and chemical properties and existing over an extensive dynamic range in biological samples. Diverse analytical techniques are needed to achieve higher coverage of metabolites. The application of mass spectrometry (MS) in metabolomics has increased exponentially since the discovery and development of electrospray ionization and matrixassisted laser desorption ionization techniques. Significant advances have also occurred in separationbased MS techniques (gas chromatography-mass spectrometry, liquid chromatography-mass spectrometry, capillary electrophoresis-mass spectrometry, and ion mobility-mass spectrometry), as well as separation-free MS techniques (direct infusion-mass spectrometry, matrix-assisted laser desorption ionization-mass spectrometry, mass spectrometry imaging, and direct analysis in real time mass spectrometry) in the past decades. This review presents a brief overview of the recent advanced MS techniques and their latest applications in metabolomics. The software/websites for MS result analyses are also reviewed.

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Metabolomics approach to explore the effects of Kai-Xin-San on Alzheimer’s disease using UPLC/ESI-Q-TOF mass spectrometry

Cited by 101 publications

References 38 publications

Novel applications of mass spectrometry‐based metabolomics in herbal medicines and its active ingredients: Current evidence

Novel applications of mass spectrometry‐based metabolomics in herbal medicines and its active ingredients: Current evidence

Screening the active compounds of Phellodendri Amurensis cortex for treating prostate cancer by high-throughput chinmedomics

Advances in mass spectrometry-based metabolomics for investigation of metabolites

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