Metabolomics analysis of the therapeutic effects of Qiwei Tongbi oral liquid on rheumatoid arthritis in rats

Tang, Ming; Gao, Xia; Geng, Tao; Chen, Xialin; Wang, Jiajia; Shen, Canjie; Gao, Huifang; Qian, Mengyu; Wang, Zhenzhong; Cao, Liang; Xiao, Wei

doi:10.1016/j.jpba.2021.114166

Cited by 13 publications

(6 citation statements)

References 25 publications

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“…The increase in the metabolism of oxologic acid may suggest that the prebiotics protect the articular cartilage because oxologic acid is a precursor of hydroxyproline, an amino acid with the most abundant content in bone collagen, and has protective effects on bone and cartilage tissue. 46 Moreover, Ming Tang et al reported a relationship between urocanic acid and rheumatoid arthritis, 47 and our study found a potential relationship between urocanic acid and PTOA. Prebiotics increased the metabolism of 3-hydroxydecanoate in PTOA mouse feces, which could promote the transportation of long-chain fatty acids into the mitochondria.…”

Section: Discussionsupporting

confidence: 71%

Prebiotics alleviate cartilage degradation and inflammation in post-traumatic osteoarthritic mice by modulating the gut barrier and fecal metabolomics

et al. 2023

Food Funct.

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Section: Discussionsupporting

confidence: 71%

Prebiotics alleviate cartilage degradation and inflammation in post-traumatic osteoarthritic mice by modulating the gut barrier and fecal metabolomics

et al. 2023

Food Funct.

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“…Phenylalanine metabolism disorder with altered level of Phenylethylamine (PEA) has been suggested in RA models and RA patients by numerous studies ( Xu et al, 2017 ; Liu et al, 2019 ; Tang et al, 2021 ). PEA is produced via decarboxylation of phenylalanine by the aromatic L-amino acid decarboxylase.…”

Section: Discussionmentioning

confidence: 99%

Traditional Tibetan Medicine Twenty-Five Wei’er Tea Pills Ameliorate Rheumatoid Arthritis Based on Chemical Crosstalk Between Gut Microbiota and the Host

Nie

et al. 2022

Front. Pharmacol.

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Twenty-Five Wei’er Tea Pills (TFP), a traditional Tibetan medicine, has shown to have a promising therapeutic effect in patients with Rheumatoid arthritis (RA), as well as being safe. Nonetheless, there have been limited pharmacological studies that have explored this therapeutic option. As gut microbiota has been proven to have a critical role in the pathogenesis of RA, this study aims to explore and reveal relevant ways by which TFP interacts with the chemical crosstalk between the gut microbiome and its host. 16S rRNA sequencing, combined with un-targeted metabolomics, were conducted on collagen-induced arthritis (CIA) rats. CIA model rats treated with TFP showed significant improvement in weight gain, pathological phenomena in joints, as well as decreased serum levels of TNF-α, IL-6 and increased level of IL-4 and IL-10. Significant dysfunction in the gut microbiome and alteration in serum metabolites were observed in CIA model rats, which were restored by TFP treatment. Coherence analysis indicated that TFP modulated the pathways of histidine metabolism, phenylalanine metabolism, alanine, aspartate, glutamate metabolism, amino sugar and nucleotide sugar metabolism owing to the abundances of Lactobacillus, Bacteroides, Prevotellaceae_UCG-001 and Christensenellaceae_R-7_group in the gut microflora. The corresponding metabolites involved L-histidine, histamine, phenylethylamine, asparagine, L-aspartic acid, D-fructose 1-phosphate, D-Mannose 6-phosphate, D-Glucose 6-phosphate, and Glucose 1-phosphate. In conclusion, this study reveals the ameliorative effects of TFP on RA through the chemical crosstalk that exists between the gut microbiota and its host, and also further enriches our understandings of the pathogenesis of RA.

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“…Results showed that SIOL increased the expression of glyoxylate and dicarboxylate metabolism pathway‐related metabolites, citric acid, and L‐serine, in the serum of RA rats. Glyoxylate and dicarboxylate metabolism is a branch of the TCA cycle (Tang et al, 2021). The TCA cycle is important for carbohydrate, lipid, and amino acid catabolism and energy metabolism (Zhang et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Saussurea involucrata oral liquid regulates gut microbiota and serum metabolism during alleviation of collagen‐induced arthritis in rats

Cong

Wang

Meng

et al. 2022

Phytotherapy Research

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Saussurea involucrata oral liquid (SIOL) can clinically relieve symptoms, such as joint pain and swelling, and morning stiffness, in patients with rheumatoid arthritis (RA).However, the mechanism of action remains unclear. This study used a combination of gut microbiota and serum metabolomics analysis to investigate the effects and potential mechanisms of SIOL intervention on rats with RA induced by type II bovine collagen and Freund's complete adjuvant. Results showed that SIOL treatment consequently improved the degree of ankle joint swelling, joint histopathological changes, joint pathological score, and expression of serum-related inflammatory cytokines (interleukin (IL)-1β, IL-4, IL-6, IL-10, and tumor necrosis factor-α) in RA model rats.16 S rRNA sequencing results showed that SIOL increased the relative richness of the Lactobacillus and Bacteroides genus and decreased the relative richness of Romboutsia, Alloprevotella, Blautia, and Helicobacter genus. Serum nontargeted metabolomic results indicated that SIOL could regulate metabolites related to metabolic pathways, such as glycine, serine, threonine, galactose, cysteine, and methionine metabolism. Spearman correlation analysis showed that the regulatory effects of SIOL on the tricarboxylic acid (TCA) cycle, phenylalanine metabolism, phenylalanine, tyrosine, and tryptophan biosynthesis, and glyoxylate and dicarboxylate metabolism pathways were correlated with changes in the richness of the Lactobacillus, Romboutsia, Bacteroides, and Alloprevotella genus in the gut microbiome. In conclusion, this study revealed the ameliorative effects of SIOL on RA and suggested that the therapeutic effects of SIOL on RA may be related to the regulation of the community richness of the Lactobacillus, Romboutsia, Bacteroides, and Alloprevotella genus, thereby improving the TCA cycle; phenylalanine metabolism; phenylalanine, tyrosine, and tryptophan biosynthesis, and glyoxylate and dicarboxylate metabolism-related pathways.

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Metabolomics analysis of the therapeutic effects of Qiwei Tongbi oral liquid on rheumatoid arthritis in rats

Cited by 13 publications

References 25 publications

Prebiotics alleviate cartilage degradation and inflammation in post-traumatic osteoarthritic mice by modulating the gut barrier and fecal metabolomics

Prebiotics alleviate cartilage degradation and inflammation in post-traumatic osteoarthritic mice by modulating the gut barrier and fecal metabolomics

Traditional Tibetan Medicine Twenty-Five Wei’er Tea Pills Ameliorate Rheumatoid Arthritis Based on Chemical Crosstalk Between Gut Microbiota and the Host

Saussurea involucrata oral liquid regulates gut microbiota and serum metabolism during alleviation of collagen‐induced arthritis in rats

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