Metabolômica De Plantas: Métodos E Desafios

Abstract

contribuiram igualmente para o trabalho e são co-autores.

A Molecular Networking Strategy: High-Throughput Screening and Chemical Analysis of Brazilian Cerrado Plant Extracts against Cancer Cells

“…Ce represents a significant carbon stock in above and below grou diversity of habitats is supported by factors such as distance from soil and groundwater, soil composition, frequency of fires, and reg number of endemic species and overall species richness make the of potential natural products discoveries and studies [2]. Metabolomic and chemometric tools have played an important role in the discovery of natural bioactive compounds by the exploration and correlation of metabolic profiles, or as dereplication strategies to avoid re-isolation of known compounds [3,4]. One of the most widely used techniques is high-resolution mass spectrometry (HRMS) which can collect data from untargeted (qualitative detection of all measurable metabolites) or targeted (quantification of a specific group of compounds) analyses [4].…”

“…Metabolomic and chemometric tools have played an important role in the discovery of natural bioactive compounds by the exploration and correlation of metabolic profiles, or as dereplication strategies to avoid re-isolation of known compounds [ 3 , 4 ]. One of the most widely used techniques is high-resolution mass spectrometry (HRMS) which can collect data from untargeted (qualitative detection of all measurable metabolites) or targeted (quantification of a specific group of compounds) analyses [ 4 ]. In molecular networking, experimental data are analyzed using algorithms to group compounds of the same class according to their mass fragmentation similarities.…”

“…One of the platforms used to perform molecular networking is Global Natural Products Social Molecular Networking (GNPS). This platform consists of an open-access web-based platform available for mass spectrometry raw data analysis (organization, processing and annotation of fragments), storage, and sharing of both raw and processed data, which enables molecular network construction applied to natural products and peptides [ 3 , 4 ].…”

New Reduction-Oxidation Indices Applied to Mixtures in the Impact on Seasonal and Circadian Rhythm Studies of The Essential Oil From Leaves of Piper Gaudichaudianum Kunth (Piperaceae) – A Folk Medicine and Ritualistic Plant

“…Obviously, this was because at that time (1998) there was not much availability of data and quanti cation techniques with greater accuracy and precision for secondary metabolites analyzes. Currently, recognizing the importance of the process of reducing oxidation of metabolism for the survival of living organisms (Gottlieb and Kaplan 1993) and the exponential growth of metabolomic analyzes (Pilon et al 2020), it is necessary the development of an index that can describe the homogeneity and the reduction-oxidation (redox) pattern in the production of the metabolism of a complex mixture for α, β and γ-chemodiversity assessments.…”

Time-Scale Shifting of Volatile Semiochemical Levels in Wild Type Lychnophora ericoides (Brazilian arnica) and Pollinator Records

“…By means of discovery of the shifting levels of metabolites concepts like chemotypes would then be feasible to check. Furthermore, chemical fingerprints have reached the status of a chemotaxonomic tool [3]. The above mentioned avant-garde status of natural products science provides valuable insights into studies regarding the biology of neotropical Compositae species, given their nature of acting as semiochemicals involved in pollination.…”