Metabolomic Study of Zuojin Pill in Relieving 1-Methyl-3-nitro-1-nitrosoguanidine-Induced Chronic Atrophic Gastritis

Tong, Yuling; Jing, Manyi; Zhao, Xu; Liu, Honghong; Wei, Shizhang; Li, Ruisheng; Liu, Xia; Wang, Min; Song, Hongtao; Yan, Zhao

doi:10.1155/2021/7004798

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…CR-EF, with a ratio of 6:1, has been used in China for a long time to treat gastrointestinal diseases, especially chronic atrophic gastritis, gastric injury, acute gastric lesions and ulcerative colitis (UC) ( Figure 3 ). Many studies have shown that ZJP can treat chronic atrophic gastritis mainly by improving gastric histomorphology and gastric tissue inflammatory lesions ( Tong et al, 2021a ; Tong et al, 2021b ; Wen et al, 2022 ). Additionally, it can alleviate gastric injury by ameliorating the inflammatory infiltration of gastric tissue ( Wei et al, 2021a ).…”

Section: Main Herb Pairs Containing Coptidis Rhizomamentioning

confidence: 99%

Several major herb pairs containing Coptidis rhizoma: a review of key traditional uses, constituents and compatibility effects

Li,

Xu,

Chen

et al. 2024

Front. Pharmacol.

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Herb compatibility is the soul of traditional Chinese Medicine prescriptions. Coptidis rhizoma (CR) (Coptis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao, or Coptis teeta Wall.; family Ranunculaceae), is a well-known herb. The bitter and cold nature of CR can irritate the spleen and stomach, and certain ingredients in CR may trigger allergic reactions. Herb combinations can help alleviate the side effects caused by CR. Through data analysis and literature research, there are many herbs combined with CR have a high frequency, but only a few are currently used as formulae in clinical practice. The results showed that these six herb pairs are usually widely studied or used as prescriptions in the clinic. This paper describes the six herb pairs from the key traditional uses, changes in bioactive constituents, and compatibility effects, especially with Euodiae fructus (family Rutaceae), Scutellariae radix (family Lamiaceae), Magnoliae Officinalis cortex (family Magnoliaceae), Glycyrrhizae radix et rhizoma (family Fabaceae), Ginseng radix et rhizoma (family Araliaceae), and Aucklandiae radix (family Asteraceae), and found that herbs are more effective when used in combination. Therefore, it is feasible to establish some methods to study herb pairs comprehensively from different perspectives. This paper aims to provide the latest and most comprehensive information on the six herb pairs and summarize the pattern of CR compatibility effects. It aims to attract more attention, and further experimental studies will be conducted to investigate and evaluate the effects of herb pairs containing CR. These data can also provide valuable references for researchers and also provide more possibilities for future applications in clinical practice and new drug development.

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Section: Main Herb Pairs Containing Coptidis Rhizomamentioning

confidence: 99%

Several major herb pairs containing Coptidis rhizoma: a review of key traditional uses, constituents and compatibility effects

Li,

Xu,

Chen

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…CR-EF, with a ratio of 6:1, has been used in China for a long time to treat gastrointestinal diseases, especially chronic atrophic gastritis, gastric injury, acute gastric lesions and ulcerative colitis (UC) (Figure 3). Many studies have shown that ZJP can treat chronic atrophic gastritis mainly by improving gastric histomorphology and gastric tissue inflammatory lesions (Tong et al, 2021a;Tong et al, 2021b;Wen et al, 2022). Additionally, it can alleviate gastric injury by ameliorating the inflammatory infiltration of gastric tissue (Wei et al, 2021a).…”

Section: Effects On the Gastrointestinal Diseasesmentioning

confidence: 99%

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Chemical components and protective effects of Atractylodes japonica Koidz. ex Kitam against acetic acid-induced gastric ulcer in rats

Zhen,

Cai,

2023

World J Gastroenterol

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BACKGROUND Atractylodes japonica Koidz. ex Kitam. (A. japonica , Chinese name: Guan-Cangzhu, Japanese name: Byaku-jutsu), a perennial herb, which is mainly distributed in northeast area of China, it’s often used to treat digestive system diseases such as gastric ulcer (GU). However, the mechanism of its potential protective effects against GU remains unclear. AIM To investigate the protective effects of A. japonica on acetic acid-induced GU rats. METHODS The chemical constituents of A. japonica were determined by ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) analysis. The rat model of GU was simulated by acetic acid method. The pathological changes of gastric tissues were evaluated by hematoxylin-eosin stain, the levels of epidermal growth factor (EGF), EGF receptor (EGFR), nuclear factor kappa-B (NF-κB), interleukin-1β (IL-1β), IL-10, Na+-K+-ATPase (NKA) in serum and gastric tissues were determined by enzyme-linked immunosorbent assay, and the mRNA expressions of EGFR, NF-κBp65, IkappaBalpha (IκBα) and Zonula Occludens-1 (ZO-1) in gastric tissues were determined by real-time reverse transcription polymerase chain reaction, and the efficacy was observed. Then, plasma metabolomic analysis was performed by UPLC-MS/MS to screen the specific potential biomarkers, metabolic pathways and to explore the possible mechanisms. RESULTS 48 chemical constituents were identified. Many of them have strong pharmacological activity, the results also revealed that A. japonica significantly improved the pathological damage of gastric tissues, increased the expression levels of IL-10, IκBα related to anti-inflammatory factors, decreased the expression levels of IL-1β, NF-κB, NF-κBp65, related to proinflammatory factors, restored the levels of factors about EGF, EGFR, ZO-1 associated with ulcer healing and the levels of factors about NKA associated with energy metabolism. Metabolomic analysis identified 10 potential differential metabolites and enriched 7 related metabolic pathways. CONCLUSION These findings contribute to the understanding of the potential mechanism of A. japonica to improve acetic acid-induced GU, and will be of great importance for the development and clinical application of natural drugs related to A. japonica.

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Metabolomic Study of Zuojin Pill in Relieving 1-Methyl-3-nitro-1-nitrosoguanidine-Induced Chronic Atrophic Gastritis

Cited by 3 publications

References 23 publications

Several major herb pairs containing Coptidis rhizoma: a review of key traditional uses, constituents and compatibility effects

Several major herb pairs containing Coptidis rhizoma: a review of key traditional uses, constituents and compatibility effects

Table1.docx

Chemical components and protective effects of Atractylodes japonica Koidz. ex Kitam against acetic acid-induced gastric ulcer in rats

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