Metabolomic profiling in patients with metabolic syndrome

Korobkova, E O; Kozhevnikova, M. V.; Ilgisonis, I S; Shakaryants, G. A.; Appolonova, Svetlana A.; Кухаренко, А. В.; Larcova, E V; Maltseva, A. A.; Khabarova, N V; Belenkov, Yu. N.

doi:10.18087/cardio.2020.3.n903

Cited by 6 publications

(1 citation statement)

References 14 publications

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“…Также с ФХ связывают образование камней в желчном пузыре, жировую болезнь печени и фиброз [5,6]. Помимо этого предполагается роль ФХ в развитии неврологических, эндокринных и психических расстройств [7][8][9].…”

Section: механизм действияunclassified

Medical rehabilitation of complications after injections of lipolytics

Иконникова

Мантурова²,

Круглова

2022

Russian Journal of Physiotherapy, Balneology and Rehabilitation

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Lipolytic injections are widely used in cosmetology practice. In most cases, they are used to correct the contours of the body, as well as to reduce the amount of fat deposits in the submental area. Side effects after their use are rare and, as a rule, resolve themselves. However, in the case of the use of non-certified medications, the frequency and severity of complications increase sharply, which requires timely and highly qualified therapy. The article presents overview data concerning the mechanism of action of the main types of lipolytics and their classification, indications and contraindications to lipolytic therapy, reveals the problems of complications that have developed as a result of their use. A description of a clinical case of the development of an inflammatory reaction after injection of a low-quality lipolytic in the area of paint fat bags is presented. The tactics of her therapy are described. This clinical case demonstrates the importance of using certified products, compliance with injection techniques and the correct choice of the patient for this method of cosmetic therapy. The article is of interest to a wide range of specialists (cosmetologists, dermatovenerologists, plastic surgeons, physiotherapists).

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Section: механизм действияunclassified

Medical rehabilitation of complications after injections of lipolytics

Иконникова

Мантурова²,

Круглова

2022

Russian Journal of Physiotherapy, Balneology and Rehabilitation

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Aromatic Amino Acids: Phenylalanine and Tyrosine in Patients with Hypertension and Coronary Artery Disease

Krivova

Kozhevnikova

Korobkova

et al. 2022

Racionalʹnaâ farmakoterapiâ v kardiologii

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Aim. To evaluate changes in the profile of aromatic amino acids (AAA) in patients with cardiovascular diseases (CVD): hypertension and coronary artery disease (CАD) in comparison with healthy study participants.Material and methods. One hundred and thirty-one participants were included in the study: 58 participants were included in the hypertension group, 46 in the CАD group, and 27 participants without signs of CVD in the control group. We used ultrahigh-performance liquid chromatography in combination with a triple quadrupole analyzer to measure plasma AAA: phenylalanine and tyrosine (Phe, Tyr) in all study participants. The association of AAA with biochemical blood test parameters, echocardiography (EchoCG) parameters, blood pressure level and clinical characteristics was analyzed.Results. A statistically significant difference in the level of concentration of Phe and Tyr was revealed (p=0,002 and p=0,024, respectively), comparing the three groups. Post-hoc analysis showed differences in the circulating level of both amino acids in patients with CAD vs the control group (Phe p=0,008 and Tyr p=0,020). Also a statistically significant difference in the level of Phe of the hypertension and CАD groups (p=0,017) was found. A negative correlation of low-density lipoproteins (LDL) with the level of Phe (r=-0,685, p<0,05) and Tyr (r=-0,583, p<0,05), as well as the level of Phe with total cholesterol (r=-0,461, p<0,05) was found in the group without CVD. In the hypertension group, only a weak positive correlation was found between very low-density lipoproteins and AAA levels (Phe r=0,326 and Tyr r=0,365, p<0,05), while in patients with CAD, the level of Phe and Tyr was negative correlated with high-density lipoprotein (r=-0,378 and r=-0,543, respectively, p<0,05), and the level of Tyr with LDL (r=0,349, p<0,05). When isolating the group with proven atherosclerosis of peripheral and/or coronary arteries, a statistically significant difference was revealed between the group of patients with CVD and clinical and instrumental signs of atherosclerosis and the group of patients with CVD without proven atherosclerosis in Phe level (p=0,019).Conclusion. Concentrations of AAA were higher in patients with CVD, comparing with the control group. At the same time, an increase of the Phe level was associated with the presence of peripheral or coronary atherosclerosis. The revealed correlations of AAA with EchoCG parameters and lipid spectrum parameters require further study to understand the involvement of AAA in pathogenesis of CVD and its potential role as treatment target.

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Understanding the nature of atherogenic disorders in children

Neudakhin¹,

Кожанова

Abramov³

2023

Ross. vestn. perinatol. pediatr.

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The article provides information about the nature of atherogenic disorders in children. Much attention is devoted to the problem of the pathogenesis of atherosclerosis, the substantiation of its stress theory, whereas nosological essence is rejected. Atherosclerosis is considered as an evolutionary, genetically determined pathophysiological process that accompanies a person from conception to death, affecting the health quality and life expectancy. Attention is drawn to the issues of susceptibility to atherogenic disorders in children, which explanation allows us to solve the problems of their prevention and prophylaxis.

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Metabolomic profiling in patients with metabolic syndrome

Cited by 6 publications

References 14 publications

Medical rehabilitation of complications after injections of lipolytics

Medical rehabilitation of complications after injections of lipolytics

Aromatic Amino Acids: Phenylalanine and Tyrosine in Patients with Hypertension and Coronary Artery Disease

Understanding the nature of atherogenic disorders in children

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