“…Together with afferent impulsion, the inflamed microenvironment induces neuronal changes. At the functional level, SAE is related to decreased brain oxygenation (Wood et al , ), metabolic shifts (Hara et al , ), and excitotoxicity (Mazeraud et al , ). The aforementioned mechanisms may be sustained in sepsis survivors with long‐term consequences such as cognitive and functional impairment (Annane & Sharshar, ), depression (Davydow et al , ), stress disorders (Wintermann et al , ), and neurological complications (Reznik et al , ).…”