Berberine Prevents Cognitive Disorders Induced by Sepsis by Regulating the Inflammatory Cytokines, Oxidative Stress and Neuronal Apoptosis in Rat Brain

Abstract

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection and can cause a huge burden to whole families and to society in terms of medical costs. Cognitive disorders induced by sepsis are still exasperating problems in clinical research. This paper examines a new measure of berberine (BBR) in sepsis induced cognitive disorders based on CLP surgery. BBR is one of many extracts from Chinese traditional herbs and exhibits antidiabetic, anticancer and antioxidant activities in treating various clinical disorders. Whether BBR shows efficacy in improving survival rates and inhibiting the extent of cognitive disorders after sepsis was explored in this paper. The result revealed that BBR treatment significantly improved the survival rate and cognitive disorders in septic rats. Increased levels of antioxidant superoxide dismutase (SOD) and reduced levels of lipid peroxidation malondialdehyde (MDA) were exhibited in the serum and brain tissue of the BBR treatment group. Moreover, the inflammatory cytokine (IL-1β, IL-4, IL-6, TNF-α) levels in the brain tissue were all decreased in the BBR treatment group compared to those in the sepsis group. BBR also largely protected the cells from apoptosis in the cerebral cortex and hippocampal CA1 region. Overall, our results indicated that BBR exhibited protective effects on survival rate and cognitive disorders after sepsis by inhibiting the release of inflammatory cytokines, oxidative stress and neuronal apoptosis in brain tissue. Therefore, BBR is a potential drug that shows efficacy in avoiding death rates and cognitive disorder after sepsis.

Renoprotective effect of JinQi-JiangTang tablet on high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats

“…It has been reported that some fractions of JQ exhibited anti-oxidative activity, it seems possible that JQ could ameliorate oxidative stress in STZ-induced diabetic rats. 22,23 To assess this, we evaluated the biomarkers of oxidative stress such as the levels of SOD, MDA, CAT and GSH-Px in renal tissue after six weeks treatment of JQ. As shown in Fig.…”

Sepsis therapies: learning from 30 years of failure of translational research to propose new leads

“…Existing drugs such as metformin (Tang et al , ) and minocycline (Adembri et al , ) show brain protective effects in experimental sepsis. The natural antioxidant berberine improved survival in a rat CLP model but also motor and cognitive functions (Shi et al , ).…”

Sağlik Profesyonelleri̇ni̇n Sepsi̇s Hakkindaki̇ Bi̇lgi̇ Ve Algilarinin Araştirilmasi

“…Sepsis, bir enfeksiyona karşı konağın uygun olmayan yanıtının neden olduğu hayatı tehdit eden çoklu organ fonksiyon bozukluğu olarak tanımlanan, insidansı ve mortalitesi yüksek bir sağlık sorunudur (1). Ülkemizde sepsis oranları hakkında yeterli veri bulunmamakla birlikte, sepsis her yıl tüm dünyada altı milyondan fazla insanın ölümüne neden olmaktadır.…”