Metabolome modulation of the host adaptive immunity in human malaria

Abdrabou, Wael; Dieng, Mame Massar; Diawara, Aïssatou; Sermé, Samuel Sindié; Almojil, Dareen; Sombié, Salif; Henry, Noelie; Kargougou, Désiré; Soulama, Issiaka; Idaghdour, Youssef

doi:10.1038/s42255-021-00404-9

Cited by 27 publications

(20 citation statements)

References 78 publications

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“…vivax-infected patients. , Elevation of steroidogenesis (pregnenolone steroids, corticosteroids, and androgen steroids) has also been reported during blood-stage malaria infection of Gouin children in Burkina Faso. , Pregnenolone (synthesized from cholesterol) has been reported as an immediate precursor for steroidogenesis that consequently gets converted into androgenic steroids and corticosteroids . Pregnenolone steroids have anti-inflammatory properties with enhanced levels of pregnenolone steroids being reported as a hallmark of malaria infection in Gouin children . We also observed an enhancement in the levels of pregnenolone steroids in the mice suffering from severe malaria (Supporting File S1), with higher levels of androgen steroids and corticosteroids being observed only in mice suffering from hyperparasitemia (Supporting File S1–S3).…”

Section: Resultssupporting

confidence: 62%

“…The serum levels of pregnenolone sulfate are elevated during severe malaria in humans. 43,79 Though we did not find pregnenolone sulfate (an endogenous antagonist of gammaaminobutyric acid) 82 in the case of severe murine malaria infections, we found lower levels of pregnenolone sulfate in uncomplicated murine malaria (Supporting File S2).…”

Section: Murine Malaria Infection Perturbs the Steroid Hormone As Wel...mentioning

confidence: 66%

“…81 Pregnenolone steroids have anti-inflammatory properties with enhanced levels of pregnenolone steroids being reported as a hallmark of malaria infection in Gouin children. 79 We also observed an enhancement in the levels of pregnenolone steroids in the mice suffering from severe malaria (Supporting File S1), with higher levels of androgen steroids and corticosteroids being observed only in mice suffering from hyperparasitemia (Supporting File S1−S3). The serum levels of pregnenolone sulfate are elevated during severe malaria in humans.…”

Section: Murine Malaria Infection Perturbs the Steroid Hormone As Wel...mentioning

confidence: 70%

“…falciparum- and P. vivax-infected patients. , Elevation of steroidogenesis (pregnenolone steroids, corticosteroids, and androgen steroids) has also been reported during blood-stage malaria infection of Gouin children in Burkina Faso. , Pregnenolone (synthesized from cholesterol) has been reported as an immediate precursor for steroidogenesis that consequently gets converted into androgenic steroids and corticosteroids . Pregnenolone steroids have anti-inflammatory properties with enhanced levels of pregnenolone steroids being reported as a hallmark of malaria infection in Gouin children .…”

Section: Resultsmentioning

confidence: 99%

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Comparative Analysis of Host Metabolic Alterations in Murine Malaria Models with Uncomplicated or Severe Malaria

et al. 2022

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Malaria varies in severity, with complications ranging from uncomplicated to severe malaria. Severe malaria could be attributed to peripheral hyperparasitemia or cerebral malaria. The metabolic interactions between the host and Plasmodium species are yet to be understood during these infections of varied pathology and severity. An untargeted metabolomics approach utilizing the liquid chromatography− mass spectrometry platform has been used to identify the affected host metabolic pathways and associated metabolites in the serum of murine malaria models with uncomplicated malaria, hyperparasitemia, and experimental cerebral malaria. We report that mice with malaria share similar metabolic attributes like higher levels of bile acids, bile pigments, and steroid hormones that have been reported for human malaria infections. Moreover, in severe malaria, upregulated levels of metabolites like phenylalanine, histidine, valine, pipecolate, ornithine, and pantothenate, with decreased levels of arginine and hippurate, were observed. Metabolites of sphingolipid metabolism were upregulated in experimental cerebral malaria. Higher levels of 20-hydroxy-leukotriene B 4 and epoxyoctadecamonoenoic acids were found in uncomplicated malaria, with lower levels observed for experimental cerebral malaria.Our study provides insights into host biology during different pathological stages of malaria disease and would be useful for the selection of animal models for evaluating diagnostic and therapeutic interventions against malaria. The raw data files are available via MetaboLights with the identifier MTBLS4387.

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Section: Resultssupporting

confidence: 62%

Section: Murine Malaria Infection Perturbs the Steroid Hormone As Wel...mentioning

confidence: 66%

Section: Murine Malaria Infection Perturbs the Steroid Hormone As Wel...mentioning

confidence: 70%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Comparative Analysis of Host Metabolic Alterations in Murine Malaria Models with Uncomplicated or Severe Malaria

et al. 2022

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“…Compared with genomics that typically captures more than 20 000 genes and proteomics that detects thousands of proteins, metabolomics as an emerging field provides information on a smaller scale comprising hundreds of metabolites. [20][21][22][23] Moreover, changes in endogenous metabolites are often smaller in extent compared to their corresponding proteins or genes that act upstream, which has somewhat limited the application of comparative metabolomics particularly in the identification of disease markers, since superior biomarkers often reflect more overt changes. To overcome these bottlenecks, innovations to enhance metabolite coverage and analytical precisions are urgently needed.…”

Section: Introductionmentioning

confidence: 99%

Precise Metabolomics Reveals a Diversity of Aging‐Associated Metabolic Features

et al. 2022

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Mass spectrometry‐based metabolomics has emerged as a powerful technique for biomedical research, although technical issues with its analytical precision and structural characterization remain. Herein, a robust non‐targeted strategy for accurate quantitation and precise profiling of metabolomes is developed and applied to investigate plasma metabolic features associated with human aging. A comprehensive set of isotope‐labeled standards (ISs) covering major metabolic pathways is incorporated to quantify polar metabolites. Matching rules to select ISs for calibration follow a primary criterion of minimal coefficients of variations (COVs). If minimal COVs between specific ISs for a particular metabolite fall within 5% window, a further selection of ISs is conducted based on structural similarities and proximity in retention time. The introduction and refined selection of appropriate ISs for quantitation reduces the COVs of 480 identified metabolites in quality control samples from 14.3% to 9.8% and facilitates identification of additional metabolite. Finally, the precise metabolomics approach reveals perturbations in a diverse array of metabolic pathways across aging that principally implicate steroid metabolism, amino acid metabolism, lipid metabolism, and purine metabolism, which allows the authors to draw correlates to the pathology of various age‐related diseases. These findings provide clues for the prevention and treatment of these age‐related diseases.

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Malaria, Immunity, and Immunopathology

Tijani,

Persson

2024

Reference Module in Life Sciences

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Metabolome modulation of the host adaptive immunity in human malaria

Cited by 27 publications

References 78 publications

Comparative Analysis of Host Metabolic Alterations in Murine Malaria Models with Uncomplicated or Severe Malaria

Comparative Analysis of Host Metabolic Alterations in Murine Malaria Models with Uncomplicated or Severe Malaria

Precise Metabolomics Reveals a Diversity of Aging‐Associated Metabolic Features

Malaria, Immunity, and Immunopathology

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