Metabolites Produced by Actinomycetes-Antiviral Antibiotics and Enzyme Inhibitors-

Uyeda, Masaru

doi:10.1248/yakushi.124.469

Cited by 8 publications

(8 citation statements)

References 52 publications

(5 reference statements)

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“…Cycloviracins are characterized by a fifth glucose unit bound to the C26 fatty acid chain, the three non-cyclic sugar units are methoxylated at C2, and the methyl branches at C2 of the fatty acid moieties are missing. Congeners of fattiviracin are divided into five families according to the length of their fatty acid moiety with each family showing similar antiviral activity against herpes, influenza and human immunodeficiency viruses (Uyeda, 2003 ). No alterations in the fatty acid chain length of cycloviracins have been reported.…”

Section: Non-trehalose Glyolipidsmentioning

confidence: 99%

Surfactants tailored by the class Actinobacteria

et al. 2015

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Globally the change towards the establishment of a bio-based economy has resulted in an increased need for bio-based applications. This, in turn, has served as a driving force for the discovery and application of novel biosurfactants. The class Actinobacteria represents a vast group of microorganisms with the ability to produce a diverse range of secondary metabolites, including surfactants. Understanding the extensive nature of the biosurfactants produced by actinobacterial strains can assist in finding novel biosurfactants with new potential applications. This review therefore presents a comprehensive overview of the knowledge available on actinobacterial surfactants, the chemical structures that have been completely or partly elucidated, as well as the identity of the biosurfactant-producing strains. Producer strains of not yet elucidated compounds are discussed, as well as the original habitats of all the producer strains, which seems to indicate that biosurfactant production is environmentally driven. Methodology applied in the isolation, purification and structural elucidation of the different types of surface active compounds, as well as surfactant activity tests, are also discussed. Overall, actinobacterial surfactants can be summarized to include the dominantly occurring trehalose-comprising surfactants, other non-trehalose containing glycolipids, lipopeptides and the more rare actinobacterial surfactants. The lack of structural information on a large proportion of actinobacterial surfactants should be considered as a driving force to further explore the abundance and diversity of these compounds. This would allow for a better understanding of actinobacterial surface active compounds and their potential for biotechnological application.

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Section: Non-trehalose Glyolipidsmentioning

confidence: 99%

Surfactants tailored by the class Actinobacteria

et al. 2015

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“…[ 7 ]. A new antiherpetic agent, fattiviracin has been isolated from Streptomyces microflavus [ 8 ]. These recent examples from the literature highlights the fact that despite extensive exploration of the actinomycetes for their antimicrobial products in the past, the search for novel molecules having unique therapeutic properties continues to be an active area of research.…”

Section: Introductionmentioning

confidence: 99%

Production of potent antimicrobial agent by actinomycete, Streptomyces sannanensis strain SU118 isolated from phoomdi in Loktak Lake of Manipur, India

2014

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BackgroundActinomycetes have provided a wealth of bioactive secondary metabolites with interesting activities such as antimicrobial, antiviral and anticancer. The study aims at isolation, characterization and the antimicrobial potentiality of Streptomyces sannanensis SU118 obtained from Phoomdi, a unique habitat of Loktak Lake of Manipur, India.ResultsAn actinomycete strain isolated from Phoomdi soil of Loktak Lake of Manipur, India was identified as Streptomyces sannanensis SU118. It is a Gram-positive filamentous bacterium which exhibits antimicrobial activity only against Gram-positive bacteria, while Gram-negative organisms were not affected. Glucose Soyabean meal broth was found to be the suitable medium for antibiotic production at 28°C for seven days of incubation. The antimicrobial agent produced by the strain was extracted with ethyl acetate as solvent and purified by thin layer chromatography. Screening and bioassay - guided fractionation of the ethyl acetate extract from the culture filtrate led to the isolation of an active potential compound (Rf value 0.56) with λmax 275.0 nm which has got the lowest minimum inhibitory concentration (0.5 μg/ml) against Staphylococcus aureus MTCC 96 and Staphylococcus aureus (clinical isolate), whereas highest (3.0 μg/ml) was recorded against Mycobacterium smegmatis MTCC 6 and Bacillus circulans MTCC 8074.ConclusionThis study has therefore uncovered the potential of exploring virgin untapped habitats in the Indo-Burma biodiversity hot spot region as reservoir of promising antimicrobial metabolite producer. These results highlighted the scope for further characterization of the metabolite and could be a candidate in the generation of new antimicrobial agents.

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“…Actinomycetes are probably the most important group of microorganisms due to their ability to produce a large number of antibiotics and other bioactive secondary metabolites [1][2][3][4][5]. In the course of screening for new biologically active compounds from marine-derived microorganisms, we found the actinomycete Saccharothrix espanaensis An 113 associated with the marine mollusk Anadara broughtoni, which produced compounds with antimicrobial activity against Gram-positive and Gram-negative bacteria, and yeast.…”

mentioning

confidence: 99%

New Angucyclinones from the Marine Mollusk Associated Actinomycete Saccharothrix espanaensis An 113

Kalinovskaya

Kalinovsky

Romanenko

et al. 2008

Natural Product Communications

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Three new angucyclinones, saccharothrixins A (6), B (7) and C (8), together with five known analogues, X-14881 A (1), X-14881 E (2), ochromycinone (3), X-14881 C (4) and X-14881 B (5), were isolated from the actinomycete Saccharothrix espanaensis An 113 associated with the marine mollusk Anadara broughtoni. The structures of the new compounds were elucidated by spectroscopic methods including one-and two-dimensional NMR and by comparison of the NMR data with those of the structurally related known angucyclinone X-14881 A (1).

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Metabolites Produced by Actinomycetes-Antiviral Antibiotics and Enzyme Inhibitors-

Abstract: F { å w å w @ ã w ò w ¤ ò w ÷ ¶¨w ª ì i §862_ 0973 F{så]{¬ 5_ 1j email: tkuyedashokeigakuen.ac.jp {àÍC½¬ 15 NxÞ¯É ½èÝEÌAEÑð SÉLq³ê½àÌÅ éD 469 YAKUGAKU ZASSHI 124(8) 469\479

Cited by 8 publications

References 52 publications

Surfactants tailored by the class Actinobacteria

Surfactants tailored by the class Actinobacteria

Production of potent antimicrobial agent by actinomycete, Streptomyces sannanensis strain SU118 isolated from phoomdi in Loktak Lake of Manipur, India

New Angucyclinones from the Marine Mollusk Associated Actinomycete Saccharothrix espanaensis An 113

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