Metabolites of the oral microbiome: important mediators of multikingdom interactions

Barbour, Abdelahhad; Elebyary, Omnia; Fine, Noah; Oveisi, Morvarid; Glogauer, Michael

doi:10.1093/femsre/fuab039

Cited by 20 publications

(12 citation statements)

References 155 publications

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“…Short-chain fatty acids, including butyrate, are also strongly associated with the pathogenesis of the periodontal disease. In the initial stage of biofilm formation, butyrate can promote early Actinomyces oris -dependent colonization and stimulate biofilm formation ( Barbour et al., 2022 ). Bacillus subtilis can produce a variety of specific metabolites.…”

Section: Methods For Detecting Bacterial Biofilmsmentioning

confidence: 99%

Understanding bacterial biofilms: From definition to treatment strategies

Zhao

Sun

Yi-pin

2023

Front. Cell. Infect. Microbiol.

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Bacterial biofilms are complex microbial communities encased in extracellular polymeric substances. Their formation is a multi-step process. Biofilms are a significant problem in treating bacterial infections and are one of the main reasons for the persistence of infections. They can exhibit increased resistance to classical antibiotics and cause disease through device-related and non-device (tissue) -associated infections, posing a severe threat to global health issues. Therefore, early detection and search for new and alternative treatments are essential for treating and suppressing biofilm-associated infections. In this paper, we systematically reviewed the formation of bacterial biofilms, associated infections, detection methods, and potential treatment strategies, aiming to provide researchers with the latest progress in the detection and treatment of bacterial biofilms.

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Section: Methods For Detecting Bacterial Biofilmsmentioning

confidence: 99%

Understanding bacterial biofilms: From definition to treatment strategies

Zhao

Sun

Yi-pin

2023

Front. Cell. Infect. Microbiol.

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“…It is recognized that bacteriocins are only one component of the biotoxic arsenal of microorganisms. Barbour et al (2022) have recently reviewed current knowledge of the contribution of a wide variety of microbial metabolites to a microbe’s life and death within the oral microbiome and the implications of this (both good and bad) for the human host.…”

Section: The Influence Of Probiotic-mediated Blis Activity On the Com...mentioning

confidence: 99%

Beneficial modulation of human health in the oral cavity and beyond using bacteriocin-like inhibitory substance-producing streptococcal probiotics

Tagg¹,

Harold²,

Jain³

et al. 2023

Front. Microbiol.

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The human oral cavity contains a diversity of microbial habitats that have been adopted and adapted to as homeland by an amazingly heterogeneous population of microorganisms collectively referred to as the oral microbiota. These microbes generally co-habit in harmonious homeostasis. However, under conditions of imposed stress, as with changes to the host’s physiology or nutritional status, or as a response to foreign microbial or antimicrobial incursions, some components of the oral “microbiome” (viz. the in situ microbiota) may enter a dysbiotic state. This microbiome dysbiosis can manifest in a variety of guises including streptococcal sore throats, dental caries, oral thrush, halitosis and periodontal disease. Most of the strategies currently available for the management or treatment of microbial diseases of the oral cavity focus on the repetitive “broad sweep” and short-term culling of oral microbe populations, hopefully including the perceived principal pathogens. Both physical and chemical techniques are used. However, the application of more focused approaches to the harnessing or elimination of key oral cavity pathogens is now feasible through the use of probiotic strains that are naturally adapted for oral cavity colonization and also are equipped to produce anti-competitor molecules such as the bacteriocins and bacteriocin-like inhibitory substances (viz BLIS). Some of these probiotics are capable of suppressing the proliferation of a variety of recognized microbial pathogens of the human mouth, thereby assisting with the restoration of oral microbiome homeostasis. BLIS K12 and BLIS M18, the progenitors of the BLIS-producing oral probiotics, are members of the human oral cavity commensal species Streptococcus salivarius. More recently however, a number of other streptococcal and some non-streptococcal candidate oral probiotics have also been promoted. What is becoming increasingly apparent is that the future for oral probiotic applications will probably extend well beyond the attempted limitation of the direct pathological consequences of oral microbiome dysbiosis to also encompass a plethora of systemic diseases and disorders of the human host. The background to and the evolving prospects for the beneficial modulation of the oral microbiome via the application of BLIS-producing S. salivarius probiotics comprises the principal focus of the present review.

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“…The oral cavity is rich in byproducts of host and OM metabolism (80). Saliva and gingival crevicular fluid (GCF) show distinct profiles of metabolite compositions between health and periodontitis (81-83) with clinical studies showing specific associations between periodontitis and increased levels of arachidonic acid, purine, pyrimidine, glutathione, and amino acid metabolites (84-87).…”

Section: Oral Metabolites and Alveolar Bonementioning

confidence: 99%

Microbiome, alveolar bone, and metabolites: Connecting the dots

Fraser

Ganesan²

2023

Front. Dent. Med

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The oral microbiome (OM) is a diverse and dynamic collection of species, separated from alveolar bone by the oral mucosa. Pathogenic shifts in the OM (dysbiosis) during periodontitis are associated with an inflammatory response in the oral mucosa that drives alveolar bone resorption. Alveolar bone is also affected by metabolic disorders such as osteoporosis. Accumulating evidence has linked another microbial community, the gut microbiome (GM), to systemic bone metabolism and osteoporosis. Underlying this connection is the biologic activity of metabolites, byproducts of host and bacterial activity. Limited evidence also suggests that metabolites in the oral cavity signal between the OM and immune system, influencing both alveolar bone homeostasis and pathologic bone destruction in periodontitis. While the oral cavity and gut are connected through the gastrointestinal tract, dissimilar roles for known metabolites between these two niches exemplify the difficulty in translating knowledge on gut-derived metabolites and bone metabolism to alveolar bone. Integrated metabolomic, transcriptomic, and metagenomic approaches hold promise for resolving these challenges and identifying novel metabolites which impact alveolar bone health. Further interrogation through mechanistic testing in pre-clinical models and carefully controlled clinical studies have potential to lead toward translation of these discoveries into meaningful therapies.

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Metabolites of the oral microbiome: important mediators of multikingdom interactions

Cited by 20 publications

References 155 publications

Understanding bacterial biofilms: From definition to treatment strategies

Understanding bacterial biofilms: From definition to treatment strategies

Beneficial modulation of human health in the oral cavity and beyond using bacteriocin-like inhibitory substance-producing streptococcal probiotics

Microbiome, alveolar bone, and metabolites: Connecting the dots

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