Metabolites from the endophytic fungus Xylaria sp. PSU-D14

Pongcharoen, Wipapan; Rukachaisirikul, Vatcharin; Phongpaichit, Souwalak; Kühn, Till; Pelzing, Matthias; Sakayaroj, Jariya; Taylor, Walter C.

doi:10.1016/j.phytochem.2008.04.003

Cited by 80 publications

(28 citation statements)

References 15 publications

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“…isolated from the leaves of Garcinia dulcis , a tropical fruit tree of southeast Asia (Pongcharoen et al, 2008). The compound exhibited moderate antifungal activity against C. albicans ATCC90028 using an agar diffusion assay (Pongcharoen et al, 2008). C. albicans is an important pathogen of human immunocompromised patients.…”

Section: Terpenoid Compoundsmentioning

confidence: 99%

The Diversity of Anti-Microbial Secondary Metabolites Produced by Fungal Endophytes: An Interdisciplinary Perspective

Mousa¹,

Raizada²

2013

Front. Microbiol.

235

121

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Endophytes are microbes that inhabit host plants without causing disease and are reported to be reservoirs of metabolites that combat microbes and other pathogens. Here we review diverse classes of secondary metabolites, focusing on anti-microbial compounds, synthesized by fungal endophytes including terpenoids, alkaloids, phenylpropanoids, aliphatic compounds, polyketides, and peptides from the interdisciplinary perspectives of biochemistry, genetics, fungal biology, host plant biology, human and plant pathology. Several trends were apparent. First, host plants are often investigated for endophytes when there is prior indigenous knowledge concerning human medicinal uses (e.g., Chinese herbs). However, within their native ecosystems, and where investigated, endophytes were shown to produce compounds that target pathogens of the host plant. In a few examples, both fungal endophytes and their hosts were reported to produce the same compounds. Terpenoids and polyketides are the most purified anti-microbial secondary metabolites from endophytes, while flavonoids and lignans are rare. Examples are provided where fungal genes encoding anti-microbial compounds are clustered on chromosomes. As different genera of fungi can produce the same metabolite, genetic clustering may facilitate sharing of anti-microbial secondary metabolites between fungi. We discuss gaps in the literature and how more interdisciplinary research may lead to new opportunities to develop bio-based commercial products to combat global crop and human pathogens.

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Section: Terpenoid Compoundsmentioning

confidence: 99%

The Diversity of Anti-Microbial Secondary Metabolites Produced by Fungal Endophytes: An Interdisciplinary Perspective

Mousa¹,

Raizada²

2013

Front. Microbiol.

235

121

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“…BCC 5484, obtained from an unidentified dead wood in Hala Wildlife Sanctuary, Narathiwat Province, Thailand [10]. PSU-D14 [19]. BCC 4297 [17].…”

Section: Cytotoxic Activity 34 Other Activities 4 Conclusionmentioning

confidence: 99%

ChemInform Abstract: Secondary Metabolites from the Genus Xylaria and Their Bioactivities

Song

Zhai

et al. 2014

ChemInform

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“…Many bioactive compounds, including antifungal agents, have been isolated from the genus Xylaria residing in different plant hosts, such as “sordaricin” with antifungal activity against Candida albicans [69] ; “mellisol” and “1,8-dihydroxynaphthol 1-O-a-glucopyranoside” with activity against herpes simplex virus-type 1 [70]; “multiplolides A and B” with activity against Candida albicans [71]. The bioactive compound isolated from the culture extracts of the endophytic fungus Xylaria sp.…”

Section: Antimicrobial Compoundsmentioning

confidence: 99%

The Use of Endophytes to Obtain Bioactive Compounds and Their Application in Biotransformation Process

Pimentel

Molina

Dionísio

et al. 2011

Biotechnology Research International

216

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Endophytes are microorganisms that reside asymptomatically in the tissues of higher plants and are a promising source of novel organic natural metabolites exhibiting a variety of biological activities. The laboratory of Bioaromas (Unicamp, Brazil) develops research in biotransformation processes and functional evaluation of natural products. With the intent to provide subsidies for studies on endophytic microbes related to areas cited before, this paper focuses particularly on the role of endophytes on the production of anticancer, antimicrobial, and antioxidant compounds and includes examples that illustrate their potential for human use. It also describes biotransformation as an auspicious method to obtain novel bioactive compounds from microbes. Biotransformation allows the production of regio- and stereoselective compounds under mild conditions that can be labeled as “natural,” as discussed in this paper.

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Metabolites from the endophytic fungus Xylaria sp. PSU-D14

Cited by 80 publications

References 15 publications

The Diversity of Anti-Microbial Secondary Metabolites Produced by Fungal Endophytes: An Interdisciplinary Perspective

The Diversity of Anti-Microbial Secondary Metabolites Produced by Fungal Endophytes: An Interdisciplinary Perspective

ChemInform Abstract: Secondary Metabolites from the Genus Xylaria and Their Bioactivities

The Use of Endophytes to Obtain Bioactive Compounds and Their Application in Biotransformation Process

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