Metabolite profile and in vitro activities of Phagnalon saxatile (L.) Cass. relevant to treatment of Alzheimer’s disease

Rosemary tea consumption results to anxiolytic- and anti-depressant-like behavior of adult male mice and inhibits all cerebral area and liver cholinesterase activity; phytochemical investigation and in silico studies

“…Moreover, Szwajgier [58] tested several phenolic acids found in beer and concluded that ferulic, p-coumaric and caffeic acids were the most potent inhibitors against cholinesterases, indicating that the type of acid, cinnamic or benzoic, as well as the presence of OH-group in para-or meta-position in the molecule elevated its inhibitory activity. Conforti et al [59] showed that caffeic acid acts as an efficient AChE inhibitor with IC 50 value 32.4 lg/mL, while luteolin had the most promising anti-AchE activity (IC 50 : 25.2 lg/mL). As far as luteolin is concerned, Dhananjayan et al [60] in a molecular docking and in vitro acetylcholinesterase inhibition study, indicated that this particular polyphenol showed the lowest IC 50 (135 lg/mL) value among other flavonoids and terpenoids, while tacrine that was used as reference had only 0.5-fold lower IC 50 (92 lg/mL).…”

Protective effects of caffeic acid against hypothalamic neuropeptides alterations induced by malathion in rat

“…Indeed, malaoxon, the most active metabolite of malathion's biotransformation, is known to inhibit AChE activity leading to its most significant effects (Abou-Donia 2003). There are few studies about the effects promoted by caffeic acid on cholinergic signaling parameters in the CNS but emerging in vitro evidence suggest that caffeic acid exerts its neuroprotective properties by inhibiting cholinesterase activities suggesting caffeic acid as a promising target compound against Alzheimer's disease (Conforti et al 2010, Oboh et al 2013). However, in vivo studies recorded a divergence in caffeic acid effects on cholinesterase's activity operating in a tissuedependent manner.…”

Antioxidant and anti-inflammatory properties of Cardiospermum halicacabum and its reference compounds ex vivo and in vivo

“…Few data are available for the glucopyranoside of apigenin-7-glucoside and luteolin-7-glucoside; that showed significant activity on NO production inhibition. Apigenin-7-glucoside showed an IC 50 value of 25 g/mL (Conforti et al, 2010), while luteolin-7-glucoside showed an IC 50 value of 20 g/mL (Hu and Kitts, 2004). These phenolic components in the ECH could also play important roles in anti-inflammatory activity.…”